Scientist / Senior Scientist, Chemical Biology (Gis)

The Yu Lab is a chemical biology lab dedicated to translational research targeting cellular nucleic acids. We integrate functional genomics, chemical biology, and molecular pharmacology to advance RNA-targeted drug discovery. Our goal is to re-engineer antisense oligonucleotides (ASOs) for gene-selective regulation, paving the way for rational drug...

**Principle Roles & Responsibilities**: Lead and design preclinical research programs focused on identifying and validating novel therapeutic targets in immunology. Develop and optimize cell-based assays, flow cytometry panels, and molecular biology techniques to support drug discovery. Participate in the evaluation of internal as well as external...

**Responsibilities**: Developing and implementing biochemical and cell-based assays for compound screening and mechanism of action studies. Interpreting and presenting research data and findings in cross-functional team meetings and scientific reviews. Collaborating effectively with a diverse team of scientists, project managers, and external partners to...

At A*STAR, we make it our mission to attract and develop a diversity of talent along the research, innovation, and enterprise value chain, with career paths developed for scientists, engineers, and entrepreneurs. In return, we commit to investing in the personal and professional growth of each of our officers. CFAR has a team of exemplary AI researchers...

**Background**: GAD at GIS has been focusing on genomics of non-human organisms including plant, bacteria, fungi, etc. The works include genome assembly, gene annotation and expression but to date we lack experts in functional genomics for these organisms that can further translate our genomic works via gene-editing (eg., CRISPR) and other forms of...

**Principle Roles & Responsibilities**: Design and execute experiments involving cancer cell lines, primary human (PBMCs) and mouse immune cells in co-culture assays with mínimal supervision. Prepare standard operating procedures and document study reports. Provide technical support for certain experimental procedures and serve as point of contact for the...

At A*STAR, we make it our mission to attract and develop a diversity of talent along the research, innovation, and enterprise value chain, with career paths developed for scientists, engineers, and entrepreneurs. In return, we commit to investing in the personal and professional growth of each of our officers. CFAR has a team of exemplary AI researchers...

Research Scientist (Metabolic Engineering Research Lab) We are seeking a highly driven research scientist to be part of a multi-disciplinary team involved in discovery of enzymes involved in biosynthesis of modified nucleotides and nucleic acids. **The research scientist will**: - Discover biosynthetic pathways for noncanonical nucleotides and DNA...

**Key Responsibilities**: Design and execute experiments to investigate gene expression in single cells and spatially resolved tissue samples Analyze data from transcriptomic and genomic assays including single cell RNAseq, spatial transcriptomics, and other sequencing technologies Develop and optimize experimental protocols for large scale single cell...

**Key Responsibilities**: Develop and implement AI-driven models for ligand discovery, with a focus on generative models. Collaborate closely with multidisciplinary teams to integrate computational methods with experimental research. Stay abreast of the latest developments in AI and molecular modelling. Communicate research findings effectively, both in...