Director of Drug Target Identification and Validation

1 week ago


Singapore TG SERVICES PTE. LTD. Full time
Roles & Responsibilities

Requirements:

Leadership and Strategy:

  • Lead and manage the drug target identification and validation team, developing strategies to discover and prioritize novel targets for therapeutic intervention.
  • Provide scientific leadership to integrate target discovery approaches such as genomic, transcriptomic, proteomic, and functional biology studies.
  • Collaborate with therapeutic area leads to ensure alignment of target discovery efforts with company goals and therapeutic focus areas.

Target Identification and Validation:

  • Lead the identification of novel drug targets through data-driven approaches, such as functional genomics (e.g., CRISPR screens), transcriptomics, proteomics, and other systems biology methodologies.
  • Drive validation of targets using in vitro and in vivo models, ensuring that selected targets have strong biological rationale and are relevant to disease mechanisms.
  • Oversee the development and application of assays and technologies for target validation, including RNA interference, gene editing, and phenotypic screening

Collaboration and Innovation:

  • Collaborate with internal drug discovery teams, including biology, chemistry, bioinformatics, and preclinical development, to advance validated targets into drug discovery programs.
  • Establish and maintain partnerships with academic institutions, CROs, and other external collaborators to leverage external expertise and technologies.
  • Stay abreast of new trends, technologies, and scientific advancements in target identification and validation, ensuring innovative approaches are applied.

Project Management:

  • Oversee project management efforts, ensuring that all target identification and validation activities are delivered on time, within scope, and on budget.
  • Lead cross-functional teams to assess target druggability, develop assays, and build disease-relevant models to support target validation.
  • Ensure appropriate resources, timelines, and risk management plans are in place to meet critical project milestones.

Regulatory and Reporting:

  • Ensure compliance with all regulatory guidelines related to target validation studies and maintain high standards of scientific rigor.
  • Prepare and present data packages, reports, and presentations to senior management, collaborators, and regulatory bodies.
  • Contribute to publications, patents, and scientific presentations to highlight advancements in target discovery and validation.

Qualifications:

Education:

  • Ph.D. in molecular biology, genetics, pharmacology, biochemistry, or related field with a strong background in target identification and validation.

Experience:

  • 7+ years of experience in drug target discovery, with a proven track record of advancing novel therapeutic targets into preclinical development.
  • -Prior experience managing cross-functional teams and drug discovery projects in a pharmaceutical or biotechnology setting.
  • Expertise in target validation methodologies such as CRISPR/Cas9, RNAi, proteomics, and high-content screening.

Skills:

  • Strong knowledge of disease biology in therapeutic areas such as oncology, immunology, neuroscience, or metabolic disorders.
  • Expertise in bioinformatics and systems biology approaches to identify and prioritize drug targets.
  • Excellent leadership, communication, and project management skills, with a demonstrated ability to manage complex discovery programs.
  • Proficiency in the design and execution of validation studies using in vitro and in vivo models.

Preferred Qualifications :

  • Experience in therapeutic areas such as metabolism, oncology, cardiovascular diseases, or autoimmune diseases.
  • Familiarity with biomarker discovery, translational research, and druggability assessments of targets.
  • Knowledge of regulatory requirements for preclinical target validation studies.
Tell employers what skills you have

Proteomics
Genomics
Translational Research
in Vivo
Systems Biology
Target Identification
in Vitro
Neuroscience
Project Management
Drug Discovery
Bioinformatics
RNA
Molecular Biology
Pharmacology
Immunology
Therapeutic Areas

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