Principal Scientist I, Wz Lab

The Yu Lab (launching in April 2025) at the Genome Institute of Singapore (GIS), A*STAR, is a chemical biology lab dedicated to translational research targeting cellular nucleic acids. We integrate functional genomics, chemical biology, and molecular pharmacology to advance RNA- and DNA-targeted drug discovery. Our goal is to re-engineer small molecules and...

Research Scientist (Metabolic Engineering Research Lab) We are seeking a highly driven research scientist to be part of a multi-disciplinary team involved in discovery of enzymes involved in biosynthesis of modified nucleotides and nucleic acids. **The research scientist will**: - Discover biosynthetic pathways for noncanonical nucleotides and DNA...

A*STAR Genome Institute of Singapore (A*STAR GIS) is seeking a Research Assistant to join us in our mission to be a leading centre of precision medicine. As an Assistant Lab Officer within our research laboratories, you will gain the opportunity to work with talented and dedicated scientists, learn from leading research experts, gain exposure and...

The HWJ lab seeks a laboratory officer to join our group at IMCB, A*STAR, Singapore. The successful applicant will work under a highly experienced Research Scientist to understand precise genetic mechanisms underlying cancer cell signalling between different cell types in 2D and 3D models. Our group develops and applies novel 2D and 3D cellular assays to...

**Principle Roles & Responsibilities**: Lead and design preclinical research programs focused on identifying and validating novel therapeutic targets in immunology. Develop and optimize cell-based assays, flow cytometry panels, and molecular biology techniques to support drug discovery. Participate in the evaluation of internal as well as external...

Be able to work as a lead scientist for the development of purification process and analytics for the production of a variety of emerging biotherapeutics, such as bispecific and multi-specific antibodies, vaccines, viral vectors and nucleic acid therapies. - Be able to lead a few research officers to work on different industrial collaboration projects and...

**Responsibilities**: Developing and implementing biochemical and cell-based assays for compound screening and mechanism of action studies. Interpreting and presenting research data and findings in cross-functional team meetings and scientific reviews. Collaborating effectively with a diverse team of scientists, project managers, and external partners to...

**Principal roles and responsibilities**: Develop and perform mammalian cell culture, biochemical, biophysical and cellular assays such as Western blotting, flow cytometry, thermal shift assays, plate-based assays involving fluorescence or luminescence for target validation and functional characterization of small and large molecule therapeutics. Support...

Lead bioinformatics projects to address key biological questions, uncover novel insights and generate novel data-driven hypotheses. Develop, implement, and optimize computational pipelines to process and analyse large-scale transcriptomic datasets, with a focus on single-cell and spatial ?Omics? data. Show increased ability to work independently and...

The Beh lab seeks to develop cutting-edge CRISPR-Cas technologies to uncover the biological functions of RNA modifications. Dysregulation of these modifications has been linked to cancer, neurological disorders, and metabolic disease. We will determine the mechanisms by which RNA modifications and CRISPR-Cas systems operate by drawing upon diverse...