Research Fellow

22 hours ago

Novena, Singapore Nanyang Technological University Full time

This Research Fellow position will play a critical role in the synthesis, purification, and characterization of proprietary chemical compounds for preclinical animal studies. In addition, this role will be actively involved in pharmacokinetics studies to evaluate compound bioavailability, metabolism, and systemic distribution. The Research Fellow will also contribute to scientific communication, project coordination, and intellectual property development.

Key Responsibilities:
1. Chemical Synthesis and Purification
- Design and execute synthetic strategies to produce proprietary chemical compounds with high purity and yield.
- Optimize reaction conditions and purification techniques, including chromatography and crystallization.
- Characterize synthesized compounds using analytical techniques such as NMR, mass spectrometry, HPLC, and LC-MS.
- Maintain detailed documentation of synthetic protocols, compound properties, and experimental observations.

2. Pharmacokinetics and Preclinical Studies
- Conduct pharmacokinetic (PK) studies to assess compound absorption, distribution, metabolism, and excretion (ADME).
- Prepare and analyze biological samples using LC-MS/MS and other relevant techniques.
- Collaborate with in vivo research teams to design and implement dosing regimens for animal experiments.
- Interpret PK data and contribute to the optimization of compound formulations for improved bioavailability.

3. Scientific and Collaborative Coordination
- Organize and facilitate regular meetings with lab members to discuss research progress and troubleshoot experimental challenges.
- Coordinate collaborative efforts with internal and external research partners, ensuring smooth information flow and project alignment.
- Assist in managing research timelines, experimental priorities, and resource allocation for ongoing studies.

4. Manuscript and Patent Drafting
- Lead and contribute to manuscript preparation, ensuring high-quality scientific writing for journal submissions.
- Conduct literature reviews to support manuscript and patent development, positioning findings within the broader scientific landscape.

5. Laboratory and Compliance Management
- Ensure adherence to safety protocols and regulatory guidelines for chemical synthesis and animal experimentation.
- Maintain laboratory inventory, including reagents, solvents, and analytical consumables.
- Train and mentor junior researchers and students in chemical synthesis techniques and analytical methodologies.

Key Requirements:

- Ph.D. in Organic Chemistry, Medicinal Chemistry, Pharmacology, or a related field.
- Strong expertise in organic synthesis, purification, and compound characterization techniques.
- Experience with pharmacokinetics studies and analytical methods such as LC-MS.
- Excellent scientific writing skills for publications and patents.
- Strong organizational and project management abilities.
- Ability to work independently while collaborating effectively with multidisciplinary teams.

Hiring Institution: LKC

  • Research Fellow

    2 weeks ago

    Novena, Singapore Nanyang Technological University Full time

    Research Fellow in the Laboratory of Asst Prof Christine Wong Siu Ling We are currently recruiting a Research Fellow who will join the laboratory of Nanyang Assistant Professor Christine Siu Ling Wong at Lee Kong Chian School of Medicine (LKCMedicine), a joint medical school between Imperial College London and Nanyang Technological University (NTU)...

  • Senior Research Fellow

    2 weeks ago

    Novena, Singapore Nanyang Technological University Full time

    The Skin Research Institute of Singapore has an opening for a Senior Research Fellow in Cellular/Molecular Biology to be located at the Clinical Sciences Building, LKCMedicine Novena. An industry funded position is open in the field of skin health. We are looking for an experienced post-doctoral research fellow with expertise in cell line derivation and...

  • Senior Research Fellow

    22 hours ago

    Novena, Singapore Nanyang Technological University Full time

    We are currently recruiting a Senior Research Fellow to join the laboratory of Professor Lim Kah Leong at the Lee Kong Chian School of Medicine (LKCMedicine), a joint medical school between Nanyang Technological University (NTU) and Imperial College London. Job Requirements - PhD in Biological Sciences or equivalent. - At least 5 years of experience as...

  • Senior/research Fellow

    4 days ago

    Novena, Singapore Tan Tock Seng Full time

    Tan Tock Seng Hospital (TTSH) Senior/Research Fellow **Job Description**: JOB SUMMARY The Programme for Research in Epidemic Preparedness and Response (PREPARE) is a national programme set up by the Ministry of Health (MOH) to support and strengthen Singapore’s key research capabilities, translational platforms, and expertise which can be harnessed to...

  • Research Fellow

    4 days ago

    Novena, Singapore Nanyang Technological University Full time

    Franklin Zhong’s lab in LKC School of Medicine is looking for a postodoctoral Research Fellow to join ongoing research on human innate immunity in skin and other barrier organs. Key Responsibilities: - Molecular biology and microbiology experiments, including genomewide CRISPR screens- Animal models of immune and skin disorders- Data analysis and...

  • Senior Research Fellow

    22 hours ago

    Novena, Singapore Nanyang Technological University Full time

    Lee Kong Chian School of Medicine (LKCMedicine) established in September 2010 is a partnership between Imperial College London and Nanyang Technological University, Singapore. The school operates from two campuses - Yunnan Campus at Nanyang Technological University and a new campus to be built at Novena. Our primary healthcare partner is the National...

  • Research Fellow

    2 weeks ago

    Novena, Singapore Nanyang Technological University Full time

    **Research Fellow (Epidemiology) in the Laboratory of **Professor John Chambers** Lee Kong Chian School of Medicine (LKCMedicine) established in September 2010 is a partnership between Imperial College London and Nanyang Technological University (NTU), Singapore. Consistently rated amongst the world's best universities, Imperial College London is a...

  • Research Fellow, Nutrition and Biological Sciences

    2 weeks ago

    Novena, Singapore Nanyang Technological University Full time

    The Lee Kong Chian School of Medicine (LKCMedicine) trains doctors who put patients at the centre of their exemplary care. The School, which offers both undergraduate and graduate programmes, is named after local philanthropist Tan Sri Dato Lee Kong Chian. Established in 2010 by Nanyang Technological University, Singapore, in partnership with Imperial...

  • Research Fellow

    4 days ago

    Novena, Singapore Nanyang Technological University Full time

    Research Fellow in Mesenchymal Stem Cells (MSCs) and Drug Discovery Lee Kong Chian School of Medicine (LKC Medicine), a joint medical school between Imperial College London and Nanyang Technological University (NTU), is currently recruiting a Research Fellow to join the laboratory of A/Prof. Yen Choo. Our lab in the new Clinical Sciences Building, located...

  • Research Fellow

    2 weeks ago

    Novena, Singapore Nanyang Technological University Full time

    **Research Fellow (Bioinformatics) **in the Laboratory of **Professor John Chambers** Professor Chambers has established and led large-scale prospective population studies in Europe, South Asia and Singapore, with these unique population cohorts leading to the discovery of novel genetic and epigenetic pathways associated with coronary heart disease, type-2...