Scientist (HWP Lab), IMCB

2 weeks ago

Singapore Agency for Science, Technology and Research Full time $80,000 - $120,000 per year

We are looking for a qualified individual to be involved in the below project. The candidate will work with a dynamic team to identify and validate candidates that address the body's adaptive responses to weight loss.

TaRgeted Analysis of Novel Secreted Factors for Obesity Reduction and Metabolic Health (TRANSFORM)

Description:

Multi-omic analysis of secreted factors from various datasets was carried out, including human, mouse and primate plasma and metabolic tissues to identify novel primate-specific secreted factors critically involved in the regulation of physiology balance. Integrative data analysis and in silico rank scoring revealed a list of promising secreted factor candidates. We will be using model organisms (e.g. mice, zebrafish) to conduct phenotypic screens and prioritize candidates for detailed validation, characterization, mode-of-action studies and therapeutic strategies.

Job responsibilities:


• Conduct in vitro wet lab experiments for identified candidates (e.g. cell culture, molecular biology and assays, protein chemistry, pharmacological efficacy etc)


• Conduct in vivo screening experiments for prioritized candidates (e.g. in preclinical models of obesity)


• Conduct end-point and mechanistic experiments (e.g. target tissue and blood collection, sample preparation etc)


• Analyze collected data and maintain accurate monitoring and reporting of experimental set-up, results and research findings


• Interact and collaborate with and assist other researchers and collaborators on related projects


• Communicate regularly with supervisor and join discussions with Principal Investigator and rest of the lab to discuss scientific progress and direction


• Assist in the preparation of grant applications and grant process reports


• Present findings both orally and in written form via presentations and publication in peer-reviewed journal


• Assist in the preparation of figures and manuscripts on the research projects for publication in peer-reviewed journals


• Contribute to other program-related projects and organizations and with the general scientific community across A*STAR

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