Senior Principal Scientist I

14 hours ago

Singapore A*STAR RESEARCH ENTITIES Remote Work Freelance Full time
The Institute of Molecular and Cell Biology (IMCB) is seeking an accomplished and visionary scientist to join us as a Principal Investigator in the field of induced pluripotent stem cell (iPSC) modeling and vascular biology . This position is aimed at strengthening IMCB's research in regenerative medicine, disease modeling, and human cell-based systems with relevance to vascular development, function, and disease.
We are looking for a principal investigator with a strong international reputation, a track record of scientific leadership, and demonstrated success in securing competitive funding. The successful candidate will lead a high-impact research programme and contribute to IMCB's strategic priorities in advancing human model systems and translational biology.
Key Responsibilities
  • Lead an independent research programme in iPSC-based modeling of vascular biology, including endothelial cell development, vascular dysfunction, and vascular contributions to complex diseases
  • Develop novel stem cell-derived platforms for studying human vascular systems and their interactions with other cell types or organs (e.g. brain, liver, tumor microenvironment)
  • Translate disease models into platforms for target discovery, therapeutic screening, or biomarker identification
  • Secure external research funding from national and international sources
  • Supervise and mentor a research team, including students and postdoctoral fellows
  • Build collaborative links with partners across A*STAR, academia, hospitals, and industry

Qualifications and Requirements
  • PhD or MD/PhD in Biomedical Sciences, Cell Biology, Developmental Biology, or a related field
  • At least 8-10 years of postdoctoral and/or independent PI experience in stem cell biology, vascular biology, or regenerative medicine
  • Internationally recognised track record of high-impact publications and scientific leadership
  • Proven success in securing competitive research funding and building productive research teams
  • Strong commitment to collaborative, interdisciplinary research and mentoring

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