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Scientist I

3 weeks ago

Singapore GDMC PTE. LTD. Full time

"Any sufficiently advanced technology is indistinguishable from magic. -Arthur C. Clarke" _

At Genetic Design and Manufacturing Corporation (GDMC), we aim to bring transformative genetic medicines to patients faster, improving their quality of life. We achieve this by focusing on partnering and supporting early-stage companies and investigator with innovative therapeutic modalities such as gene therapy or mRNA drugs. Leveraging on our expertise in process development and manufacturing, our partner companies can bring their ideas into the market as we work hand in hand with them through clinical trials. We are growing quickly and looking for talented people who are looking out for challenging opportunities to bring transformative medicines and make an impact in people’s lives.

GDMC is expanding our Process Development team and is seeking an exceptional scientist. You will evaluate and design tools to craft or improve manufacturing design of next generation therapies. You will also be exposed to various client partners and collaborate with them to design the next generation therapeutics for manufacturability. Come join us and be part of our journey to becoming the premier partnership development and manufacturing organization in Asia Pacific.

**Responsibilities**
- Assist in design and execution of cloning experiments, including plasmid construction and transformation.
- Execute studies for pre-CMC and CMC production by evaluating different microbial strains, optimizing fermentation processes, constructing plasmids, banking cells, and conducting microbial fermentations up to 10L scale.
- Gain proficiency in scaling up of processes from shake flasks to bioreactors.
- Support upstream activities which include but are not limited to basic cell culture, cell lysis, media and buffer preparation, and instrument cleaning / maintenance.
- Contribute to the writing of laboratory protocols, standard operating procedures, and other forms of routine documentation.
- Analyze experimental data, including gel electrophoresis and Nanopore sequencing data.
- Effectively communicate experimental data and their implications to internal stakeholders.

**Requirements**:

- Bachelor’s or master's degree in Biological Science and Life Science disciplines, Biotechnology, Bioengineering or related field.
- At least one year of work experience in a bioprocessing, academic or commercial process development setting.
- Familiarity in engineering and culturing _Escherichia Coli _as host for plasmid production.
- Experienced in molecular biology techniques such as DNA extraction and purification, PCR, cloning and assembly, electrophoresis, and transformation.
- Demonstrate proficiency in designing and troubleshooting experiments.
- Work authorization in Singapore.