Downstream Scientist, Scientist I

3 days ago

Singapore GDMC PTE. LTD. Full time

"Any sufficiently advanced technology is indistinguishable from magic. -Arthur C. Clarke" _

At Genetic Design and Manufacturing Corporation (GDMC), we aim to bring transformative genetic medicines to patients faster, improving their quality of life. We achieve this by focusing on partnering and supporting early-stage companies and investigator with innovative therapeutic modalities such as gene therapy or mRNA drugs. Leveraging on our expertise in process development and manufacturing, our partner companies can bring their ideas into the market as we work hand in hand with them through clinical trials. We are growing quickly and looking for talented people who are looking out for challenging opportunities to bring transformative medicines and make an impact in people’s lives.

As one of our Process Development Scientists (Downstream), you will be responsible for developing and executing downstream processes for products that we manufacture, building new processes, and closely collaborating with partner-clients / our in-house manufacturing team to optimise purification processes. You will also be exposed to novel technologies in the biotherapeutic manufacturing pipeline. Join us in building a world-changing process development team housed in our state of the art multi-million biomanufacturing facility. If you’d like to play a part in bringing the next life-saving innovations to market, we want you

**Responsibilities**
- Interact with the client partners on a daily or weekly basis to analyze their existing process for transferability and scalability.
- Manage the internal process development technicians and interns in proper laboratory techniques and scientific experimental design as necessary.
- Design and troubleshoot experiments for testing various unit operations in process development in accordance with clients need and company’s overall strategic goals.
- Develop and test novel purification strategies for Viral Vectors / mRNA / pDNA products.
- Design and test process control strategies.

**Requirements**:

- PhD in bioprocessing, pharmaceutical science, chemical engineering or equivalent for Lead role.
- BSC/MSC+ a few years of lab experience (preferably working experience with AKTA) will be considered.
- 1-5 years of work experience within bioprocessing, academic or commercial process development.
- Demonstrable proficiency in designing and troubleshooting downstream process experiments.
- Demonstrated proficiency in a wide variety of analytical and DSP techniques (E.g., SEC, IEX).
- Familiarity with developing purification processes for viral vectors (AAV, Lentivirus, Retrovirus).
- Experience in performing tech transfer processes.
- Comprehensive understanding of cGMP requirements for biomanufacturing or pharmaceutical industries.
- Familiarity in working with AAV specific purification resins (i.e., AAVX Affinity Resin).
- Experience in encapsulation of mRNA in Lipid Nanoparticles or equivalent encapsulation methods.

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