Scientist (Downstream Processing)

Overview

Esco Lifesciences Group is Singapore's most globalized life sciences company, with annual revenues close to SGD 200M and global operations in over 42 locations and 26 direct countries across North America, Europe, Asia, Oceania. Esco Aster Pte Ltd is an affiliate of Esco Lifesciences Group, founded in 2017. Esco Aster is a contract research development and manufacturing organization enabling scientists to translate bench work into commercially available products at affordable prices. Our work focuses on emerging and frontier biology utilizing cells as the final product or deriving products from cells, often using cells as the factory to derive target products. Our first commercial breakthrough is being first in the world to be certified for cultivated/cell-based meat to FSSC 22000 and by a competent food regulatory body. We operate an end-to-end integrated full cell line creation/immortalization, cell culture process development, analytical development for stem cells and exosomes with full cGMP capabilities from Drug Substance to small-scale fill & finish for final Cell Therapy Product. The work we do creates a remarkable and lasting impact on our world. You will have the opportunity to be part of this journey to own your career and gain exposure to new modalities supporting translational sciences.

Who We're Looking For

Physical/Mental Requirements/Work Environment

• Ability to read, analyze and interpret scientific data and publications.
• Ability to author or review protocols, technical reports and technology transfer documents.
• Ability to author or review standard operating procedures and other related documents.
• Ability to define problems, collect data, establish facts, and draw conclusions.
• Ability to focus.
• Repetitive motions due to certain laboratory techniques.
• Ability to adapt and keep up with rapid changes in a fluid and dynamic environment as this is a rapidly evolving space.
• Good understanding of cGMP and GDP requirements and practices.
• Able to don in the cleanroom gowning and understand aseptic behavior requirements.

The Scope

You will be part of Esco Aster's scientific division and contribute to the company's CDMO mission and objectives. You will perform research and process development activities, in various projects and in collaboration with internal and external stakeholders, clients and partners.

Primary Work Location: Ayer Rajah Crescent, Singapore

Job Responsibilities

• Work in the CDMO services as a part of the process team to develop processes for downstream unit operations for adherent cells (MSCs, iPSCs, Fibroblast, Epithelial cells, Vero, Hek293t) and derivatives (e.g. exosomes, nanovesicles, viral vectors, secreted viruses, mitochondria) as well as suspension cells for cultivated meat (mainly continuous centrifugation).
• Design, plan, execute, and supervise experimental programs.
• Analyze and interpret experiment data to draw scientific conclusions.
• Perform wet lab and /or clinical trial material activities related to downstream unit operations and associated analytics.
• Support and train subordinates on downstream techniques and operations.
• Author or review protocols, technical reports, technology transfer and training documents with scientifically supported conclusions and recommendations.
• Author or review standard operating procedures, instrument operating procedures and other lab related documents.
• Assess and implement new processes and technologies in development scale, ultimately adapting to manufacturing operations.
• Record and document data promptly and accurately maintaining data integrity.
• Assist in non-routine lab duties and administrative activities including, and not limited to procurement, vendor assessment, people management, equipment maintenance, equipment calibration etc.
• Support validation activities for new equipment as required.

Requirements

• The successful candidate will have a Bachelor or Master's degree or doctorate in Biological Sciences/(Bio)Chemical Engineering/Biological Engineering/Chemistry or related disciplines.
• At least 3-5 years' relevant experience in a life-sciences or related laboratory working with the downstream purification of stem cells/exosomes.
• Experience in filtration (NFF and TFF) unit operations and bioprocess integration.
• Knowledge of protein and molecular analyses, e.g., Western blot, qPCR, ELISA, flow cytometry etc.
• Knowledge of technical or commercial operations in the manufacture of biological molecules is desirable.
• Proficient in MS Office (Word, Excel, PowerPoint).
• Take initiatives, self-starter, research oriented, and able to work with minimum supervision.
• Possess good communication and documentation skills.
• Can contribute individually, as well as work efficiently in a dynamic team environment.

Apply now by submitting a Cover Letter and CV to

Seniority level

• Mid-Senior level

Employment type

• Full-time

Job function

• Research, Analyst, and Information Technology

Industries

• Biotechnology

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