Scientist, Target Biology

At our company, we are committed to becoming the premier research-intensive biopharmaceutical company and are dedicated to providing leading innovations and solutions for today and the future.

Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal to identify agents that are effective in treating or preventing human disease and to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities, and robust scientific methodology we collaborate to discover the next medical breakthrough.

**What You Will Do**:

- Responsibilities include, but are not limited to_
- Support the development, optimization and validation of _in vitro_ biochemical, molecular, cellular assays for target validation and hit finding studies across diverse therapeutic diseases and modalities by performing wet lab experiments as needed.
- Support drug discovery and lead optimization programs by delivering and executing on robust, quantitative screening assays and analyzing screening data to support development of data packages to enable pipeline advancements.
- Participate in team meetings and contribute to discussions on project progress and findings. Present research findings to drug discovery teams and taking ownership of data generated.
- Support the development of induced pluripotent stem cell (iPSCs) lines and mammalian cell lines by performing routine cell culture maintenance to enable development of robust assay ready cells for high throughput drug screens.
- Collaborate broadly to develop simplified, efficient assay management workflows to drive discovery programs with higher efficiency and productivity.
- Develop and implement compound plating workflows and compound inventory and management strategies to support efficient handling and organization of compound libraries, including ordering requests. Serve as primary point of contact for compound inventory and management for the site.
- Develop, implement and troubleshoot assay automation protocols to enable robust and high throughput studies for disease profiling and compound screens.
- Work in collaboration with data analytic groups to build reliable pipelines for quantitative data analysis, including participation in software upgrading activities.
- Maintain data integrity and compliance by taking ownership of the data lifecycle, perform accurate experimental record keeping and authoring documentation including SOP, assay long protocols, research reports and data presentations in collaboration with team members.
- Support and participate in various lab management and environment, health, safety initiatives as needed, including performing regular purchasing of laboratory reagents and supplies, basic maintenance and quality control of equipment and serving as primary point of contact for equipment troubleshooting.

**What You Must Have**
- To be successful in this role, you will have_
- Masters in Cell Biology/Biochemistry/Pharmacology, MSc in a Life Science-related discipline with more than five years of relevant research experience or BSc with a minimum of 8 years of relevant experience in automation and in vitro high throughput screens and assay development.
- Some experience executing and validating _in vitro_ biophysical, biochemical, molecular, cellular assays using a wide range of modern technologies and detection methods.
- Good track record in assay development, optimization, and troubleshooting.
- Experience with inventory management of samples or compounds using database software.
- Experience developing robust automation protocols for high throughput drug screens using state-of-art liquid handling platforms such as ECHO, BRAVO, Tecan, etc. is a plus.
- Good working knowledge and hands-on experience in cell culture and bio sample preparation, including 2D mammalian cell lines. Experience working with iPSC-derived models, primary cell culture, 3D organotypic cultures is a plus.
- Good understanding of cell biology and molecular biology is preferred.
- Good organizational, troubleshooting skills and knowledge in pharmacological data analysis is preferred.
- Collaborative and independent scientist that excels in a matrix environment. Possess the ability to multitask, prioritize work, attention to detail and work effectively as part of a team in a fast-paced dynamic environment.
- Willingness to learn new techniques and adapt to changing priorities. Possess a positive, proactive attitude and embodies a growth mindset.

**What You Can Expect**
- Opportunity to work at the interface of multiple disciplines and integrate cutting edge science, novel methodologies into drug discovery research.
- A supportive working environment that fosters career growth, continuous learning and diversity, equity, and inclusion.

**Search Firm Representatives Please Read Carefully**

**Employee Status**:
Temporary (Fixed Term)

**Relocation**:
*