Research Fellow

2 days ago

Singapore NATIONAL UNIVERSITY OF SINGAPORE Full time
Interested applicants are invited to apply directly at the NUS Career Portal
Your application will be processed only if you apply via NUS Career Portal
We regret that only shortlisted candidates will be notified.
Job Description
The Research Fellow will play a key role in advancing the lab's research on RNA dynamics, RNA-protein interactions, and cellular responses to toxic RNA species. The incumbent will lead and support projects exploring RNA modifications, splicing, phase separation, and RNA-related disease mechanisms, utilizing advanced molecular and cellular biology techniques, high-throughput sequencing, and proteomics. The ultimate goal is to uncover therapeutic targets and novel strategies for combating RNA-related diseases.
Key Responsibilities
Research Execution
  • Design, plan, and execute experiments to study RNA flux, RNA-protein interactions, RNA modifications, and splicing changes under stress and disease conditions.
  • Investigate the molecular mechanisms of endogenous damaged RNA and exogenous viral RNA responses.
  • Apply and further develop the lab's novel FANCI method to study RNA condensates and stress granules.
  • Perform advanced assays such as iCLIP, RNA-seq, phase separation assays, and proteomic analysis (mass spectrometry).
Scientific Contribution
  • Contribute to the discovery and characterization of RNA condensates (e.g., DHX9 stress granules) and their roles in cytoprotection, immune signaling, and autophagy.
  • Elucidate the roles of CSNK1E, PLCB2, and other regulators in antiviral immune responses using cell models, animal models, and patient-derived samples.
  • Drive hypothesis-driven projects to uncover new RNA-related disease mechanisms and potential therapeutic targets.
Collaboration & Mentorship
  • Collaborate with internal and external researchers on interdisciplinary projects.
  • Mentor and supervise graduate students, research assistants, and interns in the lab.
Knowledge Dissemination
  • Prepare manuscripts for peer-reviewed journals and present findings at conferences and seminars.
  • Contribute to grant writing and research proposals to secure funding.
Qualifications
  • PhD in Molecular Biology, Biochemistry, Cell Biology, Biomedical Sciences, or related fields.
  • Strong background in RNA biology, RNA-protein interactions, or cellular stress responses.
  • Proficiency in molecular and cell biology techniques (RNA-seq, CRISPR/Cas9, immunofluorescence, RNA immunoprecipitation, etc.).
  • Experience with RNA-centric technologies (e.g., iCLIP, RIP, phase separation assays) and/or proteomics (mass spectrometry) will be highly advantageous.
  • Experience with animal models and handling patient-derived samples preferred but not mandatory.
  • Proven publication track record in reputable journals.
  • Strong analytical skills, critical thinking, and problem-solving abilities.
  • Excellent communication skills and ability to work both independently and in a collaborative team environment.

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