Scientist / Senior Scientist (LEE lab), A*SRL
2 weeks ago
Overview We are seeking a highly motivated and skilled Scientist or Senior Scientist to join our dynamic research team at A*STAR. The ideal candidate will have a strong background in mouse disease models, cell and molecular biology, developmental biology, physiology, or related disciplines, and will contribute to a translational research project aimed at developing a novel therapeutic asset, with the goal of achieving spinoff or licensing readiness within 1-2 years. This role provides an opportunity to bridge basic science and therapeutic innovation in a collaborative, fast-paced environment with support for commercialization. Responsibilities Design and execute in vivo mouse experiments, including animal handling, compound administration (e.g., IP/IV/SC), and tissue harvesting. Isolate primary cells from mouse or human tissues; culture primary or immortalised mammalian cells. Engineer stable cell lines by designing, generating, and using lentivirus or other transgenesis systems. Perform comprehensive tissue and cell analyses using: Histological techniques (fixation, embedding, sectioning, histological staining, immunohistochemistry)Biochemical assays (Western blotting, ELISA, enzymatic assays, serum biochemistry)Molecular biology techniques including DNA/RNA extraction, PCR, qPCR, molecular cloning, and gene expression analysis Bulk and single-cell RNA sequencing Microscopy (fluorescence, confocal, and brightfield imaging)Design and validate loss-of-function strategies (e.g., RNAi, CRISPR-Cas9) for gene perturbation in vitro and in vivo. Analyze and interpret data; maintain thorough laboratory records suitable for regulatory scrutiny. Prepare technical reports, presentations, and manuscripts contributing to regulatory applications (e.g., IND) and peer-reviewed publications. Collaborate across multidisciplinary teams, including scientific, translational, and commercialization partners. Qualifications Ph.D. in Cell/Molecular Biology, Developmental Biology, Physiology, Genetics, or a related field. Hands-on experience with mouse models, including compound dosing and tissue dissection, is required. Proficiency in primary cell isolation and culture from mouse or human tissues. Strong technical skills in histology, biochemistry, and microscopy-based tissue analysis. Solid foundation in molecular biology and genetics, including construct design, cloning, RNAi, and CRISPR. Familiarity with single-cell transcriptomics or related high-dimensional platforms is advantageous. Excellent verbal and written communication skills; ability to present scientific findings clearly and effectively. Proven ability to complete and communicate scientific projects, evidenced by at least one peer-reviewed co-first authored publication. Highly organized, self-motivated, and capable of working independently and in cross-functional teams. Ability to maintain detailed laboratory records for potential regulatory filings. Comfortable working with tight timelines on a milestone-gated project. Biotech industry experience is a plus. Seniority level Associate Employment type Full-time Job function Research, Analyst, and Information Technology Industries Research Services #J-18808-Ljbffr
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Scientist (Lay Lab), A*SRL
2 weeks ago
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Scientist (Carlos Clavel lab), A*SRL
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Scientist (Stefan Oehlers Lab), A*STAR IDL
3 days ago
Singapore A*STAR - Agency for Science, Technology and Research Full timeJoin to apply for the Scientist (Stefan Oehlers Lab), A*STAR IDL role at A*STAR - Agency for Science, Technology and Research . 2 weeks ago Be among the first 25 applicants A*STAR Infectious Diseases Labs (A*STAR IDL) is seeking a Scientist to join us in our mission to be a leading centre of infectious diseases research. A*STAR IDL aims to develop a cohesive...
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Scientist (Stefan Oehlers Lab), a*STAR IDL
3 days ago
Singapore A*STAR - Agency for Science, Technology and Research Full timeDescription Join to apply for the Scientist (Stefan Oehlers Lab), A*STAR IDL role at A*STAR - Agency for Science, Technology and Research . 2 weeks ago Be among the first 25 applicants A*STAR Infectious Diseases Labs (A*STAR IDL) is seeking a Scientist to join us in our mission to be a leading centre of infectious diseases research. A*STAR IDL aims to...
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Singapore A*STAR Agency for Science, Technology and Research Full timeThe CPPS group is seeking a highly motivated scientist or senior scientist to lead in the development of AI technologies to deliver impactful and innovative digital technologies for predictive/prescriptive analytics and decision support. He/she will be expected to define growth opportunities and new ways to engage industry to advance AI for manufacturing,...
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