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The Lee Kong Chian School of Medicine is recruiting a Research Fellow for the Respiratory and Infectious Diseases Programme, Laboratory of Antimicrobial Resistance and Drug Discovery under Professor Pablo Bifani.
The laboratory focuses on applied phage biology with the aim of developing recombinant phages for therapeutic and/or diagnostic purposes. These phages are intended to treat patients affected by otherwise untreatable multidrug-resistant organisms or recalcitrant bacterial infections. The successful development of phages with therapeutic potential could have a direct impact on life-saving or quality of life improvement.
Key Responsibilities:- Perform standard microbiology techniques, including bacterial cultures and phage production, isolation, characterization, etc. The primary focus will be on the genetic manipulations/engineering of selected bacteriophages, which include knock-out, knock-in, mutagenesis, etc.
- Responsible for phage recombinant work in the lab
- Bacterial cultures
- Phage target deconvolution (understanding mechanisms of action and resistance of selected phages)
- Design and conduct experiments, including data collection and analysis
- Knowledge of bioinformatic tools would be beneficial
- Summarize and present data in lab meetings
- Develop new research techniques and approaches
- Perform maintenance of inventory and procurement of laboratory consumables
- Manage grant and basic logistical requirements associated with the project
- Ensure safe technical practices and procedures
- PhD degree in Biomedical Sciences or related fields
- Expected to have a background working with bacteria and a strong foundation in molecular biology, including recombinant work, genomic, and transcriptomic research
- Knowledge or expertise working with bacteriophages is an advantage
- Willngness to learn and comfort working with various bacteria (drug-resistant K. pneumoniae, Acinetobacter, or Mycobacterium abscessus, others)
- High adaptability in working with different organisms and techniques
- Collaborative spirit with internal and external collaborators
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