Computational Biophysicist for Drug Discovery Research

6 hours ago


Singapore NANYANG TECHNOLOGICAL UNIVERSITY Full time

The Wallenberg-NTU Postdoctoral Fellowship offers a unique opportunity to conduct cutting-edge research in computational biophysics at Nanyang Technological University (NTU).

About the Job

As a postdoctoral fellow, you will be part of a dynamic team that combines advanced molecular dynamics simulations, machine learning-driven structure prediction, and free energy calculations to identify potential small-molecule binders.

You will have the chance to work on a broad range of projects, including conformational changes and dynamics of specific proteins, utilizing machine learning frameworks to model and validate potential protein conformations, analyzing free energy landscapes, and conducting molecular docking and free energy calculations.

Your responsibilities will include:

  • Designing and executing molecular dynamics simulations to investigate protein conformational changes and dynamics;
  • Applying machine learning algorithms to predict and validate protein conformations;
  • Analyzing free energy landscapes to understand protein stability and equilibrium;
  • Conducting molecular docking and free energy calculations to predict binding affinity and efficacy;
  • Collaborating with experimental biologists to validate computational predictions through biochemical assays;
  • Working with medicinal chemists to optimize lead compounds;

We are looking for a highly motivated and skilled researcher with a strong background in computational biophysics, molecular biology, biochemistry, and drug discovery. You should have excellent computational skills, including experience with GROMACS and AMBER simulations, proficiency in programming languages like Python, and good knowledge of molecular biophysics and related fields.

In addition, you should be able to communicate effectively with colleagues from diverse backgrounds and present your research findings to various audiences.

What We Offer

Nanyang Technological University is a world-renowned institution committed to academic excellence and innovation. As a postdoctoral fellow, you will have access to state-of-the-art facilities, collaborate with leading researchers, and enjoy a competitive salary package.

We estimate a monthly salary of SGD $8,000 - $12,000, depending on your qualifications and experience.



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