Senior Principal Scientist

3 weeks ago


Singapore A*star Research Entities Full time
JobDescription:

We are seeking anAI/ML expert to drive AI in drug discovery in the area ofpharmacology and pharmacometrics, including PK/PD, in theBioinformatics Institute (BII) and Experimental Drug DevelopmentCentre (EDDC). The PI will build a research group in BII andcollaborate closely with clinicians and researchers to drive thiseffort across Singapore. The PI is also expected to lead orparticipate in grant proposals and work with industry to translatenew technologies developed.
  • Enhancecollaboration between EDDC and BII
  • Lead thepharmacology efforts in supporting all project(s), includingclinical projects. Manage and develop junior pharmacologyscientists in the IVP/BD group (in vivo pharmacology/biomarkerdevelopment).
  • Work with the Head ofComputation Sciences to drive efforts to apply ML/DL methodologiesand use predictive models to support drug discovery &development within EDDC, including but not limited toADME.
  • Contribute to AI efforts as part of thecross-functional data integration & workflow automation effortsaimed at fostering data-driven and AI-driven approaches to drugdiscovery and validation, provide support for AI-augmented drugdesign and development, addressing "undruggable' targets, andexpediting processes.
  • Establish and sustainrobust collaborative relationships with various functions withinthe Discovery unit and across relevant divisions within EDDC andBII.
  • Provide feedback as a potential end-userfor the AIDDinitiative.

JobRequirements:
  • PhD inBioinformatics, Computational Biology, Data Science, ComputerScience, Mathematics, Engineering or a related field.
  • Deep experience in AI/ML methodologies related to drugdiscovery and pharmacology.
  • 5-10 years'experience in the drug development process.
  • Outstanding record in publications, patents or securingresearch funds, or substantial industry experience.
  • Strong management skills in leading a research team,executing projects and working with multiplestakeholders.
  • Consistent track record indelivering outcomes for AI /ML projects related to healthcare andpharmacology.
  • Excellent communicationskills


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