Production Scientist

3 weeks ago

Singapore CELLVEC PTE. LTD. Full time
Roles & Responsibilities

Key responsibilities:

  • Learn and perform well-defined procedures in GMP manufacturing setting and Research and Development Settings
  • Perform equipment monitoring and basic housekeeping
  • Perform laboratory testing (e.g. pH/ conductivity/Cell density / Viability, Mycoplasma, PCR test and Flow cytometry … etc.)
  • Perform routine Clean room sanitization tasks to maintain the Clean room ISO standards
  • Demonstrate aseptic technique in the handling of product/ materials and requirement to participate in Aseptic process Simulations.
  • Multi-task exposure on cGMP manufacturing and Validation task and Research and Development trail runs.
  • Support for Protocol preparation, Execution, and summary report for Validation run and development studies
  • Attain full competency in the performance of all operations as assigned.
  • Become a technical process expert by exhibiting basic understanding of critical process/operational parameters and target/acceptable ranges, as well as interactions between different process parameters.
  • Use Standard Operating Procedures (SOPs), logbooks & Batch Manufacturing Records (BMR's) effectively & competently
  • Taking part in the internal and external audit.
  • Support for Change control, Deviations, investigations and CAPA initiation and closure
  • Assist in process development, in creating scalable processes with improved product yield and reduced manufacturing systems costs
  • Support Facilities Engineering team to perform maintenance, troubleshooting, calibration, and repair instrumentation (where applicable).

Cell Culture (Upstream)

  • Skill and knowledge of aseptic technique for thaw and subculture stages using T flasks and Cell factories, etc.
  • Knowledge of handling Cell culture, trypsinization, Centrifugation and resuspension. Cell Culture Passaging from flask / Cell factories.
  • Benchtop set up for Cell culture supernatant Clarification

Purification (Downstream)

  • Skill and knowledge of small-scale column chromatography techniques, tangential flow filtration techniques, Final Filling techniques in BSC and Isolators
  • Knowledge in handling single use chromatography columns and tangential flow filtration skids.

Key requirements:

  • Degree/Diploma in a related Science/Engineering discipline
  • 1 to 3 years relevant work experience in a similar manufacturing industry or cleanroom environment
  • Knowledge of Viral Vector manufacturing and Gene Therapy application is an added advantage.
  • Knowledge of cGMP applications
  • Positive team-oriented attitude
  • Strong communication and interpersonal skills
  • Flexible to adjust the schedule to support GMP manufacturing and R&D trial Runs.
Tell employers what skills you have

Cell
Troubleshooting
GMP environment
Chromatography
Upstream
Cell Culture
Research and Development
Purification
Flask
Flow Cytometry
Filtration
PCR
Instrumentation
Aseptic Technique
Laboratory
Manufacturing

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