Research Fellow
5 days ago
A*STAR Infectious Diseases Labs (A*STAR ID Labs) is seeking for a Research Fellow to join us in our mission to be a leading centre of infectious diseases research. A*STAR ID Labs aims to develop a cohesive A*STAR response to drive and deliver translational infectious diseases research to better health and economic outcomes.
This is a unique opportunity for a very independent computational scientist to develop their own research program, using the multitude of virus study models from our wet bench scientists as their source of data. Since we are primarily a wet lab, the position requires a high degree of autonomy, but there will be close interactions with other mathematicians and bioinformatics collaborators that have helped us develop tools throughout our work.
To implement existing computational tools, developed by our lab and collaborators, in our new lab and interface with wet bench biologists
To develop new tools to study virus population dynamics and an independent research program, using the wet bench
To use outputs of our basic research to generate innovative antiviral approaches that can foster new translational collaborations in clinical settings, in industry, in public health and surveillance or vector control.
To help train graduate students in the lab
**Examples of the tools to run and to develop**:
- Isakov O, Bordería AV, Golan D, Hamenahem A, Celniker G, Yoffe L, Blanc H, Vignuzzi M and Shomron N. (2015) Deep sequencing analysis of viral infection and evolution allows rapid and detailed characterization of viral mutant spectrum. Bioinformatics, Feb 19. pii: btv101.
Braun T, Bordería AV, Barbezange C, Vignuzzi M, Louzoun Y. Long term context dependent genetic adaptation of the viral genetic cloud. Bioinformatics. 2018 Oct 22. doi: 10.1093/bioinformatics/bty891.
Bernhauerová V, Rezelj VV, Vignuzzi M*. Modelling Degradation and Replication Kinetics of the Zika Virus In Vitro Infection. Viruses. 2020 May 15;12(5): 547. doi: 10.3390/v12050547.
Rezelj VV, Carrau L, Merwaiss F, Levi LI, Erazo D, Tran QD, Henrion-Lacritick A, Gausson V, Suzuki Y, Shengjuler D, Meyer B, Vallet T, Weger-Lucarelli J, Bernhauerová V, Titievsky A, Sharov V, Pietropaoli S, Diaz-Salinas MA, Legros V, Pardigon N, Barba-Spaeth G, Brodsky L, Saleh MC, Vignuzzi M*. Defective viral genomes as therapeutic interfering particles against flavivirus infection in mammalian and mosquito hosts. Nat Commun. 2021 Apr 16;12(1): 2290. doi: 10.1038/s41467-021-22341-7.PMID: 33863888
Sharov V, Rezelj VV, Galatenko VV, Titievsky A, Panov J, Chumakov K, Andino R, Vignuzzi M*, Brodsky L. Intra and inter-cellular modeling of dynamic interaction between Zika virus and its naturally occurring defective viral genomes. J Virol. 2021 Sep 1:JVI0097721. doi: 10.1128/JVI.00977-21. PMID: 34468175
Henningsson R, Moratorio G, Bordería AV, Vignuzzi M*, Fontes M*. DISSEQT-DIStribution-based modeling of SEQuence space Time dynamics. Virus Evol. 2019 Aug 5;5(2): vez028. doi: 10.1093/ve/vez028.
**Job Requirements**:
PhD in Applied Mathematics, Computational Biology or Bioinformatics
1 to 2 years of relevant experience
Analysing big data (OMICS) and knowledge of multi-dimensional scaling methods is particularly useful
Ambitious and independent
Team player and sociable person
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