Cell Culture

**The Opportunity**

Esco Lifesciences Group, is Singapore’s most globalized life sciences company, with annual revenues close to SGD 200M and global operations in over 20 countries across North America, Europe and Asia.

Esco Aster Pte Ltd is an affiliate of Esco Lifesciences Group and was first introduced in 2017.

At Esco Aster Pte Ltd, we are a contract development and manufacturing organization founded and deeply rooted by scientists enabling fellow scientists to translate their bench work into commercially available products and services at affordable prices.

The work we do creates a remarkable and lasting impact on our world. Join us as we redefine healthcare for the current and future generations to come.

Esco Aster.

One World. One Health.

**Responsibilities**:

- Conduct in-depth laboratory cell culture research, such as cell isolation, clone screening, cell bank establishment, cell recovery, cell passaging, stability research, etc.
- Develop, optimize and validate new cultured cell lines and new media formulation, ensuring its quality control, as well as developing specifications, SOPs and test protocols.
- Perform high-throughput screening, design of experiments (DoE) and statistical analysis to optimize cell culture processes including media.
- Responsible for driving the project and R&D team on cell culture process development and media development.
- Responsible for communication with internal and external stakeholders, including collaborators and suppliers, cross border and cross functional teams to improve efficiency and effectiveness of experiments/projects.
- Development of annual R&D plans in line with company goals, including product and technology innovation.
- Be responsible for troubleshooting and handling anomalies in the R&D process and finding solutions.
- Interface and communicate with local regulatory agencies and file for regulatory approval.
- Handle ad-hoc duties assigned by management from time to time.

**Requirements**:

- PhD degree in bioengineering, cell engineering, biochemistry, biotechnology, biopharmaceutical or related fields with preferred industrial experience of at least 3-5 years.
- The ability to engineer new cell lines for primary cells. Experience in adherent or suspension culture is preferred.
- Proficient in using flow cytometer, bioreactor, biochemical analyzer, immunofluorescence staining, qPCR assays and other assay equipment.
- Familiarity with mammalian primary cell culture processes, cell preparation and quality control. Experience in media development and optimization and understanding of mammalian metabolic pathways.
- Excellent presentation skills, communication and coordination skills and the ability to identify problems and solve them.
- Ability to design or review experimental operating procedures, write technical reports and perform proper technology transfer.
- Good communication in English and the ability to search, collect and summarize literature in relevant fields.
- Experience in project management is preferred.
- Adaptable to short-term overseas assignments.
- 2+ years of experience in cell culture and media development (experience in biopharmaceutical companies is preferred).
- Experience in media development and optimization and understanding of mammalian metabolic pathways.
- Familiarity with mammalian primary cell culture processes, cell preparation and quality control.
- Excellent presentation skills, communication and coordination skills and the ability to identify problems and solve them.
- Ability to design or review experimental operating procedures, write technical reports and technology transfer documents.
- Good communication in English and the ability to search, collect and summarize literature in relevant fields.
- Experience in project management is preferred.
- Adaptable to short term overseas assignments.