Research Fellow

5 days ago

Singapore SingHealth Group Full time

National Cancer Centre of Singapore Pte Ltd

**Research Fellow (Ref:DSSOPC-Immunology)**:

- Job Category: Research
- Posting Date: 5 Aug 2025

We are seeking a motivated and enthusiastic postdoctoral research fellow to join the Programme in Translational and Clinical Liver Cancer Research, led by Prof Pierce Chow, tenured Professor at Duke-NUS Medical School and NMRC STaR Awardee. Our Program spans the entire spectrum of Liver Cancer scientific investigations from translational research to randomized controlled trials.

A part of our research focuses on deciphering the spatial and single-cell remodeling of the tumor microenvironment (TME) in hepatocellular carcinoma (HCC) and to correlate that to clinical outcome and to response and resistance to therapeutics. The incumbent will utilize various types of patient biosamples and leverage on the insights generated from multi-omics approaches e.g. bulk tumor next-generation sequencing (NGS), cfDNA NGS, single cell RNA-seq and proteomics, CyTOF, 3D spatial transcriptomics and targeted/untargeted metabolomics in the context of a clinical cohort. Experience with interpreting the spatial data in the context of immunology is a requirement. In addition, the incumbent is also expected to perform wet bench research to interrogate and validate the functions of shortlisted targets, as well as investigating their values as biomarkers of therapy response and resistance. Expertise in spatial-omics approaches, cancer models, immunohistochemistry, and translational research is highly desirable.
- Your responsibilities will include:

- Perform wet bench research to interrogate and validate the functions of shortlisted targets, as well as investigating their values as biomarkers of therapy response and resistance.
- Interpret spatial data in immunological context.

**Requirements**:

- PhD (or MSc with strong research experience) with relevant experience in cancer research, immunology, or a related field.
- Experience with the following will be essential:

- Molecular biology techniques (including qPCR and Western blot).
- Functional genomics approaches (such as RNA-seq, ChIP-seq, scRNA-seq, spatial tools).
- Flow cytometry/CyTOF (especially high-parameter flow).
- Immunohistochemistry/immunofluorescent staining.
- Cell culture and in vitro assays (proliferation, cell death, cell cycle, etc).
- Possess excellent analytical, technical and problem-solving skills.
- Well organized and detail oriented.
- Ability to coordinate diverse groups of people.
- Excellent written and verbal communication skills.
- Able to work independently and interactively in a team setting, motivated, responsible and a fast learner.
- Req ID: 4234

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