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**Key Responsibilities**:
Experimental Design and Execution:
- Plan, design, and conduct experiments related to antibody discovery, including immunization strategies, hybridoma generation, phage display, yeast display and molecular cloning.
- Perform hands-on laboratory work, including sample preparation, cell culture, immunizations, and antibody screening.
Antibody Screening and Characterization:
- Develop and optimize high-throughput screening assays to identify antibodies with desired properties such as specificity, affinity, and functionality.
- Conduct antibody characterization assays, such as ELISA, Western blot, flow cytometry, and functional assays.
Antibody engineering:
- Employ protein engineering techniques to optimize antibodies, improving their affinity, stability and pharmacokinetic properties.
Data Analysis and Documentation:
- Analyse experimental data using appropriate statistical methods and software tools.
- Maintain detailed and accurate laboratory notebooks, experiment records, and electronic databases.
- Prepare reports, summaries, and presentations for team meetings and project updates.
Innovation and Problem Solving:
- Stay updated with the latest advancements in antibody discovery techniques and propose innovative approaches to enhance the efficiency and success of the research.
Laboratory Management:
- Maintain laboratory equipment and ensure proper functioning. Troubleshoot and perform basic maintenance when necessary.
- Manage and order laboratory supplies to ensure smooth workflow.
**Qualifications**:
- Bachelor’s or Master’s degree in Immunology, Molecular Biology, Biochemistry, or a related field.
- Hands-on experience with antibody discovery techniques such as hybridoma generation, phage display, or related methodologies.
- Proficiency in molecular and cell biology techniques.
- Familiarity with protein expression techniques like mammalian and bacterial protein expression and purification. Protein analysis techniques such as ELISA, Western blot, and flow cytometry is desirable.
- Strong data analysis skills using software tools like Excel, GraphPad Prism, or similar.
- Excellent organizational skills and attention to detail.
- Strong written and verbal communication skills.
- Ability to work collaboratively in a team-oriented environment.
- Prior experience in a biotechnology company is a plus.
Work Environment: This is a full-time position based in a fully equipped research facility. The applicant will work closely with a collaborative team of scientists and researchers dedicated to advancing antibody discovery efforts for use in therapeutics and diagnostics. The applicant will report to the Head of Antibody Discovery.
Note: The above description is designed to indicate the general nature and level of work performed by an employee in this position. It is not to be interpreted as an exhaustive list of all responsibilities, duties, and skills required for this role.
