Research Officer/ Senior Research Officer

**Research Officer / Senior Research Officer
- Tumour Organoid Research (STCC)**

Overview

The Consortium for Clinical Research and Innovation, Singapore (CRIS) brings together six national R&D, clinical translation and service programmes to advance clinical research and innovation for Singapore and establish important capabilities for a future-ready healthcare system. The Business Entities under CRIS include:

- Singapore Clinical Research Institute (SCRI)
- National Health Innovation Centre (NHIC)
- Advanced Cell Therapy and Research Institute, Singapore (ACTRIS)
- Precision Health Research, Singapore (PRECISE)
- Singapore Translational Cancer Consortium (STCC)
- Cardiovascular Disease National Collaborative Enterprise (CADENCE)

Together, CRIS makes a positive difference to Singapore patients and researchers by ensuring that these clinical research platforms and programmes are at the cutting edge of capability development and innovation. If you are as passionate as we are in clinical trials and research, we want you

**STCC**

STCC; a nationally coordinated consortium to synergise cancer research capabilities in Singapore, brings together unmatched basic, clinical, and translational talent in Singapore to create globally significant peaks of excellence in selected Asian cancers.

STCC's five joint platforms - Cancer Clinical Trials and Investigational Medicine Units, Cancer Databases and Tissue Banks, Translational Research Integration and Support, Business Intelligence and Development, and Impact and Population Health - provide an enabling research and innovation environment driven to foster translational research and meaningful outcomes for society.

Through collaborative relationships with our partner institutions [comprising of National Cancer Centre Singapore (NCCS), National University Cancer Institute, Singapore (NCIS), National University Hospital (NUH), National University of Singapore (NUS) and Tan Tock Seng Hospital (TTSH)], and by capitalizing on the strengths of industry and academia, STCC is uniquely poised to develop initiatives that are aligned with Singapore's goals in value-based healthcare innovation and economic value creation.

STCC is a business unit of the Consortium for Clinical Research and Innovation, Singapore (CRIS), and is supported by the National Research Foundation, Singapore (NRF) and the Singapore Ministry of Health through the National Medical Research Council (NMRC) Office, MOH Holdings Pte Ltd.

**The Role**:

- Perform patient-derived organoid (PDO) culture, co-ordinate with multiple organoid research groups for collection and propagation of organoids for national level projects.
- Optimize protocols for tumour organoid culture and expansion.
- Establish and implement standardized workflows for organoid collection, organoid culture, expansion, molecular characterization and clinical annotations for collaborative studies.
- Conduct cellular and molecular assays such as RNA/DNA extraction, qPCR, Immunofluorescence, H&E staining, High-throughput compound screening, Cytotoxicity assays, Next-Generation Sequencing (NGS) etc.
- Organize and co-ordinate meetings with organoid research groups and industry partners.
- Compile and curate a national list of available tumour organoid models with associated annotations, protocols, and SOPs from collaborators.
- Support the development of STCC national tumour organoid catalogue.
- Capable of working in a team to survey scientific literatures, optimize standard protocols, execute and troubleshoot as seen appropriate.
- Review scientific literature, troubleshoot protocols, and contribute to protocol optimization.
- Maintain high standards of research integrity, including meticulous documentation and execution.
- Demonstrate strong initiative, willingness to learn, and the ability to work effectively within a multidisciplinary team.
- Participate in and present research findings at group meetings and conferences.
- Prepare technical reports, risk assessments, and SOPs.
- Adhere to laboratory safety procedures and perform other duties as required.

**Qualifications**
- Bachelor’s Degree in Cancer Biology, Molecular Biology, Immunology, or other strongly related scientific discipline.
- Prior experience with cell culture, 3D cell culture, organoid models and molecular biology techniques is highly desirable.
- Preferably with 2-5 years’ experience in a clinical or research laboratory setting.
- Experience in Next-Generation Sequencing
- Able to learn new techniques, perform multiple tasks simultaneously and deliver quality work under tight timelines.
- Meticulous with an attention to details.
- Team player, good interpersonal, communication and presentation skills.
- Proficient in Microsoft Office, e.g. PowerPoint, Word and Excel.

What you need to know

For more information about CRIS and the Business Entities, visit our websites below: