Senior Scientist

We are committed to becoming the premier, research-intensive biopharmaceutical company and are dedicated to providing leading innovations and solutions for today and the future. Our mission is to discover, develop, and provide medicines and vaccines that save and improve lives around the world. We strive to transform breakthrough science into novel therapeutics and vaccines, and our scientific curiosity drives us to invent solutions to some of the world's most challenging diseases.

In Singapore, our Research Centre is located within the Biopolis, the heart of Singapore's biomedical research community. Here, we are focused on identifying and validating new drug targets, exploring innovative therapeutic modalities, and leveraging clinical studies. We use disease or therapeutic response biomarkers to increase our understanding of human biology and drive a therapeutic pipeline to address unmet medical needs. Our state-of-the-art laboratory supports discovery biology and translational medicine and is an integral part of our company’s world-class network for drug and vaccine discovery.

**Overview**:
The Discovery Cardio-metabolic Diseases (CMD) is currently seeking a Senior Scientist with strong experience in bioanalytical assay development to join our Molecular Biomarkers team at the Singapore site. In this role, you will be accountable for developing, validating and deploying biomarker assays on Cardio-Metabolic Disease (CMD) projects, using samples from animal models and patients, with the goal of driving patient stratification, demonstrating target engagement, evaluating pharmacodynamic response, and guiding dose selection.

Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough.

**WHAT YOU WILL DO**
- Develop and execute robust bioanalytical assays to support cell-based, in vitro, and in vivo studies.
- Work closely with Discovery Biology, In Vivo Pharmacology and Translational Medicine teams to support biomarker studies.
- Work with limited supervision on experimental design, troubleshooting, assay optimization and data interpretation.
- Make detailed observations, analyze data, interpret results, and exercise appropriate technical discretion in the design and execution of experiments.
- Participate in and communicate the interpretation of research results in cross-functional team meetings.
- Keep up to date with emerging biomarker technology platforms and evaluate their utility in providing novel insights into disease biology.
- Accurately document experiments and results in electronic notebooks and/or other required formats in compliance with company policies and project needs.
- Coordinate preventive maintenance for laboratory equipment, troubleshoot equipment malfunction, and support the team in routine operational activities for the laboratory.
- Assist in training personnel in the operation of laboratory equipment as needed.
- Identify areas of improvement in existing workflows and leverage the effective use of resources to support operational efficiency.

**WHAT SHOULD YOU HAVE**:

- M.Sc in analytical chemistry, biochemistry, or equivalent, with 5+ years or B.Sc with 10+ years’ experience working in a bioanalytical or a quality control (QC) laboratory, preferably at an biotechnology or biopharmaceutical company.
- Hands-on experience with the design, development, optimization, qualification, and validation of novel bioassays and immunoassays using multiple platforms and technologies.
- Experience with protein analytical methods (e.g., SDS-PAGE, Western Blotting).
- Experience with sample processing methods to support protein and nucleic acid detection from a variety of tissue types.
- Track record of developing technical methods and SOPs.
- Experience working in a GxP environment, and CRO management for method transfer will be an added advantage
- Strong problem solving and troubleshooting skills.
- Detail oriented with strong time management skills.
- Good prioritization and operational skills.
- Strong interpersonal and verbal/written communication skills.
- Effective team player that has a positive, proactive, can-do attitude.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

**Who we are**

We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing