Senior Scientist, Quantitative Biosciences

Our Research Scientists are our Inventors. We discover and target steps in disease mechanisms or pathways with the goal to identify agents that are effective in treating or preventing human disease. Using innovative thinking, state-of-the-art facilities, and robust scientific methodology we collaborate to discover the next medical breakthrough.

**Key responsibilities**:

- Design, optimize, and execute state-of-the-art wet-bench methodologies to enable drug discovery efforts through the execution of disease-relevant target-based and phenotypic assays in cellular models using high content, 3D advanced imaging technologies.
- Utilize your background and experience in cell biology to perform tissue culture with established cell lines and primary cultures, including organotypic cultures.
- Establish relevant cellular based functional assays for functional genomic screens in both pooled and arrayed format to identify novel targets using translational models.
- Develop, adapt, and implement new research techniques and validate protocols for new assays, enabling their integration into standard workflows.
- Work as part of an interdisciplinary team to support research strategies and project goals, critically analyzing data and contribute ideas that will drive projects forward.

**Qualifications**:

- PhD in Cell or Molecular Biology, imaging, pharmacology, bioengineering or equivalent, together with at least 3 years of post-doctoral experience; or an M.S. degree with a minimum of 6 years of relevant experience; or a B.Sc./B.A. degree with a minimum 10 years of relevant experience.
- Highly skilled in the design, development, and execution of quantitative high-complexity cell assays, using a wide range of modern technologies and detection methods.
- Have good working knowledge and experience with physiologically relevant cellular models (iPSC-derived models, human primary cells, 3D cultures) with quantitative detection methods.
- Demonstrable technical expertise in histology (i.e. immunohistochemistry (IHC), tissue sectioning, in-situ hybridisation), light and fluorescence microscopy, advanced confocal and wide-field microscopy.
- Experience with molecular biology techniques, including CRISPR genome editing, flow cytometry, next-generation sequencing and CRISPR screens is highly desirable.
- Experience with high-content assay development, miniaturization and automation protocols to enable high throughput studies using automated image analysis tools, algorithms and data analysis is desirable.
- Solid experimental design, troubleshooting and data analysis skills.
- Ability to multitask, prioritize work and establish strong collaborations and relationships to stakeholders.
- Comfortable working in a matrix environment and handling several concurrent fast paced projects.
- A proven track record of high productivity and scientific publications in peer reviewed journals.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

**Who we are**

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

**What we look for**

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization.

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

**Search Firm Representatives Please Read Carefully**

**Employee Status**:
Regular

**Relocation**:
Domestic/International

**VISA Sponsorship**:
Yes

**Travel Requirements**:
No Travel Required

**Flexible Work Arrangements**:
Not Specified

**Shift**:
Not Indicated

**Valid Driving License**:
No

**Hazardous Material(s)**:
**Requisition ID**:R232358