Senior Lead Scientist

Singapore, Tuas SingaporeToday, Lonza is a global leader in life sciences operating across three continents. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that’s the kind of work we want to be part of.

Did you know that we are the 1st biologics contract manufacturer in Singapore? We offer you exposure to upcoming biotech and established pharmaceutical companies and to the manufacturing technology needed to produce mammalian treatments and cell therapies of tomorrow. Our global manufacturing network is recognized for its reliable, high-quality services, regulatory track record, global footprint, innovative technology platforms and extensive experience - we, in Singapore are proud to be part of this global network.

You will be joining the Analytical Services team within Development Services in Lonza Singapore, focusing on **protein characterization using mass spectrometry and other analytical methods**. The Development Services group is responsible for the development and characterization of manufacturing processes used for the production of novel therapeutic recombinant proteins for Lonza’s global client base. The role holder will be responsible for leading studies in the Characterization team, ensuring that projects are delivered in a timely and efficient manner, training and development junior members of the team and driving innovative improvements. The team perform studies to characterize biopharmaceuticals to ensure a comprehensive understanding of the molecule attributes and to generate fully qualified and characterized reference materials that can be used as part of subsequent cGMP batch release testing in the QC laboratories.

**Key Responsibilities**:

- Demonstrated experience with methods and instruments used for protein characterization such as **LC-MS (peptide mapping, intact mass analysis and oligosaccharide profiling), icIEF, CE-SDS, HPLC (SEC, RP, HIC, IEX, HILIC)** and **SEC-MALS** including expertise in the analysis of the resultant data.
- Collate, analyze and interpret data to communicate progress and escalate challenges to Line Manager, project teams and customers as appropriate.
- Exercise technical discretion in the design, execution and interpretation of experiments for product characterization and biocompatibility studies per relevant ICH regulatory guidelines.
- Review and approve GMP documentation e.g. SOPs, protocols and reports, regulatory documents as required
- Leading problem solving investigations and supports OOS/Aberrant result investigations as required.
- Provide leadership to junior team members through their expert scientific knowledge.
- Manage multiple studies and discuss data changes/discrepancies (through both written reports and verbal presentations).
- Deliver high quality communication to ensure an outstanding customer experience (written reports, teleconferences and face to face meetings).
- Lead improvement projects and driving new innovations within the analytical function.
- Facilitate communication between other departments in Singapore and across the global Lonza network (e.g. Development/MSAT/QC/QA/Program Management) relevant to area of expertise.
- Demonstrate flexibility to support other activities within the Analytical Services department
- Should be able to demonstrate a clear understanding of the relevant ICH guidelines in the area of protein characterization.
- Lead improvements in scientific practice and identify error traps within the laboratory and within processes to improve standards.
- Execution of multiple projects simultaneously, ensuring work is planned and scheduled appropriately and delivered to agreed timelines and quality standards.

**Key Requirements**:

- Minimum Degree with 8 years work experience or PhD with 6 years’ postdoctoral with relevant recombinant protein analyses experience.
- Practical laboratory experience using LC-MS systems is required
- Experience working in a cGxP/CMC analytical environment would also be considered advantageous.
- Good problem solving and analytical skills along with good communication and team working required.
- To work to the highest scientific standards with minimum oversight from the Line Manager

Every day, Lonza’s products and services have a positive impact on millions of people. For us, this is not only a great privilege, but also a great responsibility. How we achieve our business results is just as important as the achievements themselves. At Lonza, we respect and protect our people and our environment. Any success we achieve is no success at all if not achieved ethically.

People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfac