Upstream Scientist

4 days ago

Singapore SGVECTOR PTE. LTD. Full time

About the Job

Job responsibilities:

- Perform plasmid cloning, transformation, amplification, and purification.
- Maintain mammalian cell cultures using aseptic techniques.
- Set-up and operate benchtop and large-scale single use bioreactors (50L)
- Perform molecular biology and analytical assays such as SDS-PAGE, Western blot, flow cytometry, ELISA and qPCR to support the upstream and downstream PD efforts.
- Utilize DoE methodology to optimize cell growth and viral vector titers in suspension mammalian cell cultures.
- Collaborate with team members to identify and evaluate process improvements with the goal of optimizing the current rAAV production process.
- Draft and edit lab protocols, standard operating procedures, sampling plans, technical reports, and batch records for regulatory or tech transfer purposes.
- Search literature for methods, processes, and assess new equipment and technologies in order to expand and improve upstream AAV capabilities.
- Work with senior team members to perform and understand process experiments and characterization studies.

**Requirements**:

- Tertiary degree with relevant industry experience in Chemical Engineering, Pharmaceutical Engineering, Biomedical Engineering, Cell and Molecular Biology, Biochemistry, Biotechnology or related fields.
- Hands-on experience with mammalian cell expression technology and media optimization, using suspension-based bioreactor systems is required.
- Prior experience in process development and preferably also GMP manufacturing of viral vector products is required.
- Experience working in a BSL-2 environment and using aseptic techniques.
- A highly motivated team player with an ability to be productive and a willingness to learn in a fluid, fast-paced and environment are essential.
- Excellent organizational and collaborative skills, with the ability to design and troubleshoot experiments with mínimal supervision or as part of a group.

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