Scientist / Senior Scientist (LEE lab), A*SRL

2 weeks ago

Singapore A*STAR RESEARCH ENTITIES Remote Work Freelance Full time
We are seeking a highly motivated and skilled Scientist or Senior Scientist to join our dynamic research team at A*STAR. The ideal candidate will have a strong background in mouse disease models, cell and molecular biology, developmental biology, physiology, or related disciplines, and will play a key role in a well-funded translational research project aimed at developing a novel therapeutic asset, with the goal of achieving spinoff or licensing readiness within 1-2 years. This role provides a unique opportunity to bridge basic science and therapeutic innovation in a collaborative, fast-paced environment with strong institutional support for commercialization.
Key Responsibilities
  • Design and execute in vivo mouse experiments, including animal handling, compound administration (e.g., IP/IV/SC), and tissue harvesting.
  • Isolate primary cells from mouse or human tissues, cell culture of primary or immortalised mammalian cells.
  • Engineering of stable cell lines by designing, generating, and using lentivirus or other transgenesis systems.
  • Perform comprehensive tissue and cell analyses using:
  • Histological techniques (e.g., fixation, embedding, sectioning, histological staining, immunohistochemistry)
    • Biochemical assays (e.g., Western blotting, ELISA, enzymatic assays, serum biochemistry)
    • Molecular biology techniques, including DNA/RNA extraction, PCR, qPCR, molecular cloning, and gene expression analysis.
    • Bulk and single cell RNA sequencing
    • Microscopy (e.g., fluorescence, confocal, and brightfield imaging)
  • Design and validate loss-of-function strategies (e.g., RNAi, CRISPR-Cas9) for gene perturbation in vitro and in vivo.
  • Analyze and interpret data.
  • Maintain thorough laboratory records that will withstand regulatory scrutiny.
  • Prepare technical reports, presentations, and manuscripts that may eventually contribute to regulatory applications (e.g. IND) and peer reviewed publications.
  • Collaborate across multidisciplinary teams, including scientific, translational, and commercialization partners.

Job Requirement
  • Ph.D. in Cell/Molecular Biology, Developmental Biology, Physiology, Genetics, or a related field.
  • Demonstrated hands-on experience with mouse models, including compound dosing and tissue dissection, is required.
  • Proficiency in primary cell isolation and culture, including from mouse or human tissues.
  • Strong technical skills in histology, biochemistry, and microscopy-based tissue analysis.
  • Solid foundation in molecular biology and genetics, including construct design, cloning, RNAi, and CRISPR.
  • Familiarity with single-cell transcriptomics or related high-dimensional platforms is advantageous.
  • Excellent verbal and written communication skills, including the ability to present scientific findings clearly and effectively.
  • Proven ability to complete and communicate scientific projects, as evidenced by at least one peer-reviewed co-first authored publication.
  • Highly organized, self-motivated, and capable of working independently and in cross-functional teams.
  • Needs to be able to maintain detailed laboratory records to be used for potential regulatory filings.
  • Comfortable working with tight timelines and on a milestone-gated project.
  • Biotech industry experience is a plus.

  • Scientist / Senior Scientist (LEE lab), A*SRL

    7 days ago

    Singapore A*STAR - Agency for Science, Technology and Research Full time

    Overview We are seeking a highly motivated and skilled Scientist or Senior Scientist to join our dynamic research team at A*STAR. The ideal candidate will have a strong background in mouse disease models, cell and molecular biology, developmental biology, physiology, or related disciplines, and will contribute to a translational research project aimed at...

  • (Senior) Research Fellow/research Scientist

    2 weeks ago

    Singapore A*STAR Agency for Science, Technology and Research Full time

    The A*STAR Skin Research Labs (A*SRL) Fellowship Programme aims to identify, mentor and nurture aspiring researchers in the field of skin research. The programme provides exceptionally talented and promising scientists, with a background in skin research or related areas, the opportunity to set up and independently run their own research projects. A*SRL...

  • Lab Scientist

    4 weeks ago

    Singapore Corning Incorporated Full time

    Overview Role: Lab Scientist (Contractual) at Corning Incorporated. The Singapore lab scientist will design, execute, and analyze experiments to help develop new products and processes and optimize existing processes. Uses scientific methods to design, analyze and report on experiments to solve difficult technical problems or enhance fundamental...

  • Data Scientist, AI Lab

    4 weeks ago

    Singapore OCBC Full time

    Join to apply for the Data Scientist, AI Lab role at OCBC . Who We Are As Singapore's longest established

  • Senior Research Scientist

    3 hours ago

    Central Singapore Emprego SG Full time

    **Location** Singapore, Central Singapore **Job Type** **Date Posted** 1 hour ago Additional Details **Job ID** 1661 **Job Views** 4 **Job Description**: **Job Description**: Senior Research Scientist Position Available - Toshio Suda Lab 1. Senior Research Scientist **Experience**: **Requirements**: Prof Toshio Suda Senior Principal...

  • Senior Scientist/Scientist, Electromagnetics and Time Metrology

    1 week ago

    Singapore A*STAR Research Full time

    Senior Scientist/Scientist, Electromagnetics and Time Metrology (NMC)Job Description We are seeking a motivated and talented Senior Scientist/Scientist to join our optical clock development team. This position focuses on supporting the research, design, and development of optical atomic clocks , with an emphasis on ultra-high vacuum (UHV) chamber design and...

  • Lab Scientist/senior Scientist

    7 days ago

    Singapore AB Agri Full time

    **Location**: Singapore with Travel Do you have experience working in a Chemistry-based laboratory and a keen interest in sharing your knowledge and expertise with others? If so, we have an exciting opportunity that combines science, travel, and business for you! As the key regional contact for our laboratory services in ASPAC. A key part of your role will...

  • Scientist/senior Scientist, Artc

    7 days ago

    Singapore A*STAR Agency for Science, Technology and Research Full time

    **The key roles & responsibilities include**: Research into novel learning-centric optimization algorithms for efficient multi-resource planning. Work with a team of scientists and engineers to enhance and develop the planning capabilities of existing or new enterprise decision-support system Formulate scientific research directions and innovative proposals...

  • Lab Scientist

    4 weeks ago

    Singapore Corning Incorporated (Asia Region) Full time

    Overview Designs, executes, and analyzes experiments to help in developing new products and processes and optimize existing process. Uses scientific methods to design, analyze and report on experiments to solve difficult technical problems or enhance fundamental understanding. Serves as a technical expert in field. The Singapore lab scientist will also...

  • Scientist/Senior Scientist, mRNA Process Development

    2 weeks ago

    Singapore A*STAR - Agency for Science, Technology and Research Full time

    Overview Scientist/Senior Scientist, mRNA Process Development Join to apply for the Scientist/Senior Scientist, mRNA Process Development role at A*STAR - Agency for Science, Technology and Research The Nucleic Acid Therapeutics Initiative (NATi), hosted by A*STAR, is Singapore's national platform dedicated to advancing RNA-based medicines and...