Scientist, Laboratory of Chemical Biology and Functional Genomics
4 days ago
Overview The Yu Lab has an opening position for Scientist to join our team and contribute to innovative RNA-targeted therapeutic discovery. We are a chemical biology lab dedicated to translational research targeting cellular nucleic acids. This project is to engineer antisense oligonucleotides (ASOs) for gene-selective regulation, paving the way for precision medicine. By leveraging cutting-edge gene-targeting strategies, structural biology, sequencing technologies, and computational approaches, we aim to unlock RNA as a precise therapeutic target, addressing diseases linked to genomic dysregulation and undruggable pathways. Contract length: 13-month contract for the first instance Responsibilities Lead the design and optimize RNA-targeting strategies in cells. Lead in designing and conducting experiments related to CRISPR, small-molecule screening, and ASO development. Perform molecular biology experiments, including CRISPR-based gene regulation, plasmid construction, stable cell line establishment, and RNA-seq library preparation. Maintain lab operations, including reagent preparation, consumable ordering, budget tracking, and equipment maintenance. Engage in literature reviews, research discussions, and collaborative projects. Ensure project milestones are met and contribute to manuscript preparation. Requirements PhD degree in Biological Sciences, Chemical Biology, or related fields. Experience in ASO design, molecular biology, cell culture, RNA biology, CRISPR, or sequencing technologies. Strong organizational skills and a positive, eager-to-learn attitude. Ability to work both independently and collaboratively in a fast-paced research environment. Application Details For inquiries or to apply, please email your CV and brief research interest to Zutao Yu ( ), with email title "Scientist application_A*STAR". More information about the lab can be found online: and About GIS The Genome Institute of Singapore (GIS), A*STAR is the national flagship program for genomic sciences in Singapore, with a mission to use genomics to improve public health and drive biomedical innovation. GIS offers a highly competitive remuneration package and relocation assistance. Singapore is a vibrant, cosmopolitan city-state at the heart of Asia, known for its excellent quality of life, world-class research infrastructure, and strong government support for scientific innovation. Join us in advancing RNA and DNA-targeted therapeutics and making an impact in functional genomic medicine#J-18808-Ljbffr
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