Lead Scientist, Purification

1 week ago

Singapore Lonza Biologics Tuas Pte. Ltd. Full time

Today, Lonza is a global leader in life sciences operating across three continents. While we work in science, there's no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that's the kind of work we want to be part of.

Did you know that we are the 1st biologics contract manufacturer in We offer you exposure to upcoming biotech and established pharmaceutical companies and to the manufacturing technology needed to produce mammalian treatments and cell therapies of tomorrow. Our global manufacturing network is recognized for its reliable, high-quality services, regulatory track record, global footprint, innovative technology platforms and extensive experience - we, in Singapore are proud to be part of this global network.

The successful applicant for this position will be joining Purification Development team within Development Services in Lonza Singapore. The Development Services group is responsible for the development and characterization of manufacturing processes used for the production of novel therapeutic recombination proteins for Lonza's global client base. The purpose of this role is to lead and execute studies, provide technical expertise for downstream process development activities and to support troubleshooting activities at both laboratory and manufacturing scale.

..The position will be primarily based in Tuas.

Key Responsibilities:

  • The role holder will lead downstream purification development or characterization studies with recombinant proteins, employing his/her in-depth understanding of chromatography, filtration and other purification techniques to develop existing processes and develop novel purification strategies.
  • Design experimental plans to validate process robustness, scalability and cost-effectiveness while ensuring compliance with regulatory standards.
  • Plan, prioritize and execute platform and novel experimental design for process development activities with strong problem-solving skills and a high level of attention to detail to deliver high quality science.
  • Execute multiple projects simultaneously, ensuring work is planned and scheduled appropriately and delivered accurately to agreed timelines and quality standards.
  • Author or review protocols, technical reports and technology transfer documents with scientifically supported conclusions and recommendations in accordance with Lonza policies and current Good Manufacturing Practices (cGMP).
  • Active involvement in communication delivered by the team to ensure an outstanding customer experience (written reports, teleconferences, face-to-face meetings).
  • Contribute to manufacturing deviation investigations where input from the Development team is required.
  • Collaborate with other departments locally and in Lonza's global network to ensure consistency in technical approach and procedures.
  • Proactively contributes to operational efficiency initiatives and general lab support including housekeeping, equipment maintenance, inventory of supplies, etc.

Key Requirements:

  • Degree/Master/PhD in Biological Science/Engineering or Equivalent
  • Minimum 5 years' work experience in purification development obtained in a relevant industrial environment or in academia.
  • Extensive experience in purification process development or characterization and be familiar with laboratory scale execution of various techniques including affinity and ion exchange chromatography using the AKTA system, ultrafiltration/diafiltration and viral reduction strategies.
  • Strong understanding and demonstrated application of theory involved in purification of recombinant proteins.
  • Documented track record of delivering projects of increasing complexity.
  • Excellent problem solving and analytical skills.
  • Excellent communication skills (verbal and written).
  • Excellent teamworking skills.
  • Experience in technology transfer and/or the use of DoE methodologies would be considered advantageous.
  • Understanding of cGMP regulations will be advantageous.

Every day, Lonza's products and services have a positive impact on millions of people. For us, this is not only a great privilege, but also a great responsibility. How we achieve our business results is just as important as the achievements themselves. At Lonza, we respect and protect our people and our environment. Any success we achieve is no success at all if not achieved ethically.

People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference.

Vaccination status: As the above role requires you to work on-site., only fully vaccinated.. employees will be shortlisted for the role. For fully vaccinated applicants, please indicate your vaccination status as 'fully vaccinated' when applying for the role.

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