Biotechnologist, Mammalian Manufacturing

2 weeks ago

Singapore Lonza Biologics Tuas Pte. Ltd. Full time

Today, Lonza is a global leader in life sciences operating across three continents. While we work in science, there's no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that's the kind of work we want to be part of.

Did you know that we are the 1st biologics contract manufacturer in We offer you exposure to upcoming biotech and established pharmaceutical companies and to the manufacturing technology needed to produce mammalian treatments and cell therapies of tomorrow. Our global manufacturing network is recognized for its reliable, high-quality services, regulatory track record, global footprint, innovative technology platforms and extensive experience - we, in Singapore are proud to be part of this global network.

We have a number of great opportunities for Biotechnologists to join our Manufacturing Team at our Tuas site in Singapore. Reporting to the Section Lead/Manager, you will be responsible for the manufacturing of therapeutic proteins under cGMP conditions.

You will be working in 12-hour rotating shift in a 2-2 3-2 2-3 pattern and will be compensated with shift premium and allowances

Key responsibilities:

  • Learn and perform well-defined procedures within a GMP manufacturing setting
  • Perform equipment monitoring & and basic 6S housekeeping
  • Perform basic laboratory tasks (e.g. sampling, pH/ conductivity/ osmolality measurements etc.)
  • Perform routine sanitization tasks to maintain facility standards
  • Trained & signed off on Performance Measures (PMs) relating to CIP/ SIP/ basic tank & instrument operations
  • Demonstrate aseptic technique in the handling of product/ materials
  • Perform basic process & equipment troubleshooting
  • Multi-task on equipment preparations & operations to ensure adherence to schedule
  • Attain full competency in the performance of all operations relevant to manufacturing areas assigned.
  • Display basic process & equipment troubleshooting ability under routine scenarios.
  • Become a technical process expert by exhibiting basic understanding of critical process/operational parameters and target/acceptable ranges, as well as interactions between different process parameters.
  • Use Standard Operating Procedures (SOPs), logbooks & Batch Records (BRs) effectively & competently
  • Submit samples via Laboratory Information Management System (LIMS)

Cell Culture (Upstream small/ scale)

  • Skill and knowledge of aseptic technique for subculture stages example using culture flask, spinners, wave bioreactors, etc.
  • Technical knowledge on the bioreactor culture control example pH/DO control, CO2/O2 control, cell performance, and metabolites analysis.

Purification (Downstream small scale)

  • Skill and knowledge of column chromatography techniques, tangential flow filtration techniques, micro/Nano filtration techniques, pH/Conductivity adjustment techniques, aseptic techniques.
  • Technical knowledge on the chromatography operating interface example using UNICORN software and various DeltaV control parameters for chromatography and UF operation.
  • Knowledge in single use applications for the respective processes.

Key requirements:

  • Degree/Diploma in a related Science/Engineering discipline
  • Some relevant work experience in a similar manufacturing industry or cleanroom environment
  • Knowledge of Biopharmaceutical processing is an added asset
  • Knowledge of cGMP applications
  • Positive team oriented attitude
  • Strong communication and interpersonal skills
  • Willing to perform rotating 12-hour shift pattern

Every day, Lonza's products and services have a positive impact on millions of people. For us, this is not only a great privilege, but also a great responsibility. How we achieve our business results is just as important as the achievements themselves. At Lonza, we respect and protect our people and our environment. Any success we achieve is no success at all if not achieved ethically.

People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference.

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