Process Development Scientist

2 weeks ago


Singapore VALERE SG PTE. LTD. Full time

Responsibilities

  • Interact with the client partners on a daily or weekly basis to analyze their existing process for transferability and scalability.
  • Manage the internal process development technicians and interns in proper laboratory techniques and scientific experimental design as necessary.
  • Design and troubleshoot experiments for testing various unit operations in process development in accordance with clients need and company's overall strategic goals.
  • Develop and test novel purification strategies for Viral Vectors / mRNA / pDNA products.
  • Design and test process control strategies.

Requirements:

  • PhD in bioprocessing, pharmaceutical science, chemical engineering or equivalent for Lead role.
  • BSC/MSC+ a few years of lab experience (preferably working experience with AKTA) will be considered.
  • 15 years of work experience within bioprocessing, academic or commercial process development.
  • Demonstrable proficiency designing and troubleshooting downstream process experiments.
  • Demonstrated proficiency in a wide variety of analytical and DSP techniques (E.g., SEC, IEX).

Desired Qualifications

  • Familiarity with developing purification processes for viral vectors (AAV, Lentivirus, Retrovirus).
  • Experience in performing tech transfer processes.
  • Comprehensive understanding of cGMP requirements for biomanufacturing or pharmaceutical industries.
  • Familiarity in working with AAV specific purification resins (i.e., AAVX Affinity Resin).
  • Experience in encapsulation of mRNA in Lipid Nanoparticles or equivalent encapsulation methods.


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