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Singapur, Singapore A*STAR Research Full timeOverview The A*STAR—NRF Postdoctoral Award (NRF-PA), jointly supported by Singapore’s Agency for Science, Technology and Research (A*STAR) and the National Research Foundation (NRF), is a prestigious programme designed to attract and empower outstanding early-career researchers. The fellowship focuses on cultivating AI talents and driving innovation and...
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Research Scientist
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Join to apply for the Research Scientist (BPIS), IMCB role at A*STAR - Agency for Science, Technology and Research Queenstown, Central Singapore Community Development Council, Singapore Job Description & Requirements We seek a dynamic PhD graduate with 1–2 years of experience and strong hands‑on laboratory experience in molecular cell biology, genomics, and bioinformatics data analysis to support the BioPharma Innovations and Solutions (BPIS) team, focusing on both wet‑lab and bioinformatics work for in‑house and collaborative projects. Key Responsibilities Support BPIS in setting up in vitro & cell‑based assays, including primary, secondary, and mechanistic assays for targets of interest. Maintain and manage a variety of mammalian cell lines, including induced pluripotent stem cells (iPSCs); execute iPSC differentiation protocols to generate neuronal, liver, and gut cell types; ensure high experimental quality, consistency, and reproducibility. Design, execute, and troubleshoot DNA cloning and vector development for gene expression and functional studies; develop and validate stable, engineered cell lines for long‑term assays. Develop in vitro 2D & 3D (organoids, organ‑on‑chip) models for developmental neurotoxicity, hepatotoxicity, genotoxicity assessments, and other disease/target‑focused drug/genetic screening studies. Utilise transient gene‑silencing (siRNA/shRNA) and stable genome‑editing technologies (CRISPR‑based); conduct downstream functional and phenotypic assays to characterise model systems and outcomes. Execute genomics workflows including WGS, RNA‑seq, DNA methylation‑seq, ATAC‑seq, and ChIP‑seq; perform sample and library preparation for next‑generation sequencing studies. Conduct end‑to‑end genomic data analysis using NGS pipelines (QC, alignment, quantification, differential analysis, visualization); develop workflows in R and Python, leveraging RStudio and Bioconductor packages. Integrate wet‑ and dry‑lab workflows, interpret findings, and contribute to hypothesis development for ongoing research programmes. Lead development of new analytical approaches; support manuscript preparation, presentations, and publication activities. Job Requirements PhD in Molecular Biology, Pharmacology, Biochemistry, Genomics, Bioinformatics, or a related discipline, with demonstrated hands‑on laboratory and bioinformatics experience. Solid experience with mammalian cell culture, maintenance, expansion, and quality control of multiple cell lines; proficiency with iPSCs and directed differentiation protocols. Strong technical experience in DNA cloning, vector design, and construct generation; proficiency in siRNA/shRNA and CRISPR/Cas2‑based genome editing. Proven experience in performing and analysing genomics sequencing (WGS, WES, ATAC‑seq, ChIP‑seq, etc.); proficiency in molecular & cell‑biological techniques (qPCR, western blot, immunofluorescence, microscopy). Strong programming and data‑science skills with R and Python; experience developing reproducible pipelines and workflows for large‑scale genomic/transcriptomic data processing. Demonstrated ability to structure analytical projects and codebases for robustness, scalability, version control, and reproducibility; excellent written and oral communication skills. Collaborative mindset and interpersonal skills, contributing to an inclusive, open, and knowledge‑sharing team environment. For further information, please contact Dr Lakshmanan Manikandan ( ‑star.edu.sg). Recruitment Details Seniority level: Associate Employment type: Full‑time Job function: Other (Research Services) #J-18808-Ljbffr
