Scientist/ Snr Research Officer, Process Development

2 weeks ago

Singapur, Singapore A*STAR Full time

? Job Description

Process Development Joint Lab (PDJL) between Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR) and Advanced Cell Therapy and Research Institute Singapore (ACTRIS) aims to advance pre-GMP process and analytical development of cell therapy assets to support seamless transition towards GMP manufacturing. The PDJL will work closely with industry solution providers and in partnership with ACTRIS collaboratively support and advance development of novel cell therapy assets from local academia, national healthcare groups and biotech companies with the ultimate aim of translating them into GMP-compliant workflows for clinical-scale manufacturing.

We are looking for industry experienced Process and Analytical Development Scientist with GMP, GLP and CMC experience to join this exciting translational fronting initiative to support with Process and Analytical Development for advancing cell therapy modalities. Selected candidates will support with project management, technology transfer activities and will be actively involved in planning and execution of cell therapy process and analytical development studies in order to establish GMP-ready standard operating protocols and assay methods for tech transfer to GMP manufacturing. Roles and responsibilities of candidates will include but not limited to the following:

·Technology Transfer of cell therapy pipelines (CAR-T, TCR-T, NK, ??-T, TILs, iPSC-derived cells) from asset developers to PDJL and subsequent transfer of established methods and SOPs to GMP manufacturing team

·Gap assessment to identify studies required for optimizing unit operations and establishing integrated manufacturing workflows.

·Plan and execute studies for optimization and development of standardized assay methods for evaluating critical quality attributes of manufactured cells.

·Establish and execute scale-down DoE studies to optimize critical process parameters for manufacturing unit operations.

·Establish standardized manufacturing workflows using modular manufacturing platforms or automated manufacturing platforms as well as scale-up of process where required.

·Support with process related investigations and perform root cause analysis for issues arising during GMP manufacturing runs at CMO and peform necessary follow-up studies.

·Support Project management activities to ensure efficient and timely execution of activities, meticulous documentation of studies in GLP compliant manner and routine communication to update GMP partners and CT asset owners.

·Perform data analysis, prepare technical reports, establish standard operating protocols and assay methodology for tech transfer to GMP team.

·Training of GMP personal on manufacturing workflows and QC personal on assays

·Provide scientific guidance to Associate Scientists

·Perform other related duties incidental to the work described therein.

Job Requirements

·Masters or PhD in Immunology, Life Sciences, Biomanufacturing or in a relevant Science field or equivalent BioEngineering or Biotechnology field

·Candidates with BSc and relevant industry experience will be considered as well.

·Industry or relevant experience in cell therapy manufacturing and/or cell therapy related analytical assay development.

·Prior experience in handling and management of BSL-2 viral pathogens (retrovirus, lentivirus, Sendai virus)

·Prior experience in handling immune cell cultures such as TCR-T, CAR-T, NK, gamma-delta-T cells

·Practical experience with biomanufacturing platforms such as G-REX, Miltenyi CliniMacs Prodigy, Lonza Cocoon, Wave or Stirred Tank bioreactors.

·Technical knowledge in cell therapy related CMC and GMP requirements, GLP compliance, FMEA analysis, process technology transfer and/or ICH compliant assay development

·Experience in Flow cytometry, ELISA assays, xCelligence real-time cell analyzer, multiplex cytokine assays

·Familiarity with DoE methodologies

·Possess interpersonal communication skills with excellent written and oral communications.

·Demonstrate excellent quantitative, analytical, troubleshooting, time-management and organizational skills.

·Strong team player who is independent, highly motivated and work collaboratively in an interdisciplinary team and diverse workforce.

  • Cyber Security Scientist/ Snr Engineer

    1 month ago

    Singapur, Singapore ST Engineering Full time

    Title: Cyber Security Scientist/ Snr Engineer Job ID: Location: Aero - West Camp Road, SG Description: ST Engineering is a global technology, defence and engineering group with a diverse portfolio of businesses across the aerospace, smart city, defence and public security segments. The Group harnesses technology and innovation to solve...

  • Cyber Security Scientist/ Snr Engineer

    4 weeks ago

    Singapur, Singapore ST Engineering Full time

    Title: Cyber Security Scientist/ Snr Engineer Job ID: Location: Aero - West Camp Road, SG Description: ST Engineering is a global technology, defence and engineering group with a diverse portfolio of businesses across the aerospace, smart city, defence and public security segments. The Group harnesses technology and innovation to solve...

  • Research Scientist, CFAR, IHPC

    2 weeks ago

    Singapur, Singapore A*star Research Entities Full time

    Job Description:The research scientist will be responsible for designing novel methods and theories for testing and enhancing the fairness of foundation models.The research scientist will be responsible for supervising local and international students.The research scientist will implement the codes and system for AI fairness testing and enhancement.The...

  • Research Fellow/Research Scientist

    2 weeks ago

    Singapur, Singapore A*star Research Entities Full time

    We are seeking to recruit a highly motivated Research Fellow/Research Scientist to support the institute's overall Research and Innovation goals.Job Description:The Research Fellow/Research Scientist will be responsible for engineering novel CAR-NK cells with superior anti-tumor efficacy, enhanced tumor infiltration, and excellent resilience against the...

  • Research Scientist

    2 weeks ago

    Singapur, Singapore A*star Research Entities Full time

    Purpose of Job:A research scientist is needed to develop detailed ammonia-hydrogen facility designs as base cases and parametric study for HAZOP, FMEA and QRA. These assessments will form the basis for the identification of critical scenarios needed to model and simulate toxic dispersion, fire and deflagration/detonation. The work will entail the development...

  • Research Scientist

    1 month ago

    Singapur, Singapore NTU (Nanyang Technology University- Main Office-HR) Full time

    We invite suitable candidate to join a strong research team in Temasek as a Research Scientist.Key Responsibilities:Conduct research in digital signal processing, in particular the detection and localization of active and passive targets via wireless RF signals in the harsh environmentConduct both theoretical development of methods and experiment design to...

  • Scientist/Senior Scientist, ARTC

    2 weeks ago

    Singapur, Singapore A*star Research Entities Full time

    The Advanced Remanufacturing and Technology Centre (ARTC) is a public-private partnership consortium of more than 80 industry members. Our core mission is to develop and deploy advanced manufacturing solutions and upskill the workforce to drive local industry competitiveness. Smart Virtual Systems (SVS) Group is seeking a highly motivated Scientist/ Senior...

  • Research Fellow/Research Scientist

    2 weeks ago

    Singapur, Singapore A*star Research Entities Full time

    We are seeking to recruit a highly motivated Research Fellow/Research Scientist to support the institute's overall Research and Innovation goals.Job Description:The Research Fellow/Research Scientist will be responsible for engineering novel CAR-NK cells with superior anti-tumor efficacy, enhanced tumor infiltration, and excellent resilience against the...

  • Research Fellow/Research Scientist

    4 weeks ago

    Singapur, Singapore A*STAR RESEARCH ENTITIES Full time

    Roles & ResponsibilitiesWe are seeking to recruit a highly motivated Research Fellow/Research Scientist to support the institute’s overall Research and Innovation goals.Job Description:The Research Fellow/Research Scientist will be responsible for engineering novel CAR-NK cells with superior anti-tumor efficacy, enhanced tumor infiltration, and excellent...

  • Research Fellow/Research Scientist

    4 weeks ago

    Singapur, Singapore A*STAR RESEARCH ENTITIES Full time

    Roles & ResponsibilitiesWe are seeking to recruit a highly motivated Research Fellow/Research Scientist to support the institute’s overall Research and Innovation goals.Job Description:The Research Fellow/Research Scientist will be responsible for engineering novel CAR-NK cells with superior anti-tumor efficacy, enhanced tumor infiltration, and excellent...

  • Scientist (IMRE)

    2 weeks ago

    Singapur, Singapore A*star Research Entities Full time

    Job Overview:The Institute of Materials Research and Engineering (IMRE), part of the Agency for Science, Technology, and Research (A*STAR), is looking for a research scientist to join the development of an integrated quantum photonics platform, with a focus on integrated single-photon detectors. The scientist will be heavily involved in developing the device...

  • Research Scientist

    2 weeks ago

    Singapur, Singapore A*star Research Entities Full time

    The Innovation & Enterprise Fellowship Programme (IFP) seeks to grow the pool of deep-tech talent in Singapore with the capabilities to support the commercialisation of deep-tech research and bring nascent technologies to market. Targeting researchers, scientists, and engineers (RSEs), the programme aims to develop industry relevant innovation and...

  • Research Fellow/Research Scientist

    4 weeks ago

    Singapur, Singapore A*STAR RESEARCH ENTITIES Full time

    Roles & ResponsibilitiesWe are seeking to recruit a highly motivated Research Fellow/Research Scientist to support the institute’s overall Research and Innovation goals.Job Description:The Research Fellow/Research Scientist will be responsible for engineering novel CAR-NK cells with superior anti-tumor efficacy, enhanced tumor infiltration, and excellent...

  • Research Fellow/Research Scientist

    4 weeks ago

    Singapur, Singapore A*STAR RESEARCH ENTITIES Full time

    Roles & ResponsibilitiesWe are seeking to recruit a highly motivated Research Fellow/Research Scientist to support the institute’s overall Research and Innovation goals.Job Description:The Research Fellow/Research Scientist will be responsible for engineering novel CAR-NK cells with superior anti-tumor efficacy, enhanced tumor infiltration, and excellent...

  • Research Scientist

    2 weeks ago

    Singapur, Singapore A*star Research Entities Full time

    We are seeking motivated and enthusiastic research scientists to join our team. The successful candidate will work closely with our PI, Co-Is and researchers to develop and test the integration of CO2 capture and carbonation of incineration bottom ash (IBA) for decarbonation and waste management in Singapore. This role will involve conducting experiments,...

  • Research Scientist

    2 weeks ago

    Singapur, Singapore Nanyang Technological University Full time

    The School of Electrical and Electronic Engineering invites applications for the position of Research Scientist.The Research Scientist will work on a project to conduct the research on development of high-power motor system.Key Responsibilities: Development of new motor design for electric motor drives, focusing on loss and thermal analysis. Development of...

  • Research Scientist

    4 weeks ago

    Singapur, Singapore A*STAR RESEARCH ENTITIES Full time

    Roles & ResponsibilitiesThe Innovation & Enterprise Fellowship Programme (IFP) seeks to grow the pool of deep-tech talent in Singapore with the capabilities to support the commercialisation of deep-tech research and bring nascent technologies to market. Targeting researchers, scientists, and engineers (RSEs), the programme aims to develop industry...

  • Research Scientist

    4 weeks ago

    Singapur, Singapore A*STAR RESEARCH ENTITIES Full time

    Roles & ResponsibilitiesThe Innovation & Enterprise Fellowship Programme (IFP) seeks to grow the pool of deep-tech talent in Singapore with the capabilities to support the commercialisation of deep-tech research and bring nascent technologies to market. Targeting researchers, scientists, and engineers (RSEs), the programme aims to develop industry...

  • Scientist/ Snr Research Officer, Analytical Development

    1 week ago

    Singapur, Singapore A*STAR Full time

    ? Job Description We are looking for experienced Analytical Development Scientist with GMP, GLP and CMC experience to join this exciting translational fronting initiative to support with Process and Analytical Development for advancing cell therapy modalities. Selected candidates will support with project management, technology transfer activities and...

  • Research Scientist/Senior Research Scientist

    1 month ago

    Singapur, Singapore Tate & Lyle Full time

    As  Research Scientist / Senior Research Scientist, you will be a key technical leader in R&D and Solutions Innovation, a group within the Tate & Lyle Innovation & Commercial Development (ICD) Division and will play a key role to act as the center of product development process, including concept development, business case creation, product design and...