Scientist (Downstream Processing)

**The Opportunity**

Esco Lifesciences Group, is Singapore’s most globalized life sciences company, with annual revenues close to SGD 200M and global operations in over 20 countries across North America, Europe and Asia.

Esco Aster Pte Ltd is an affiliate of Esco Lifesciences Group and was first introduced in 2017.

At Esco Aster Pte Ltd, we are a contract development and manufacturing organization founded and deeply rooted by scientists enabling fellow scientists to translate their bench work into commercially available products and services at affordable prices.

The work we do creates a remarkable and lasting impact on our world. Join us as we redefine healthcare for the current and future generations to come.

Esco Aster.

One World. One Health.

**Who we’re looking for**

**Physical/Mental Requirements/Work Environment**
- Ability to read, analyze and interpret scientific data and publications.
- Ability to author or review protocols, technical reports and technology transfer documents.
- Ability to author or review standard operating procedures and other related documents.
- Ability to define problems, collect data, establish facts, and draw conclusions.
- Ability to focus.
- Repetitive motions due to certain laboratory techniques.
- Ability to adapt and keep up with rapid changes in a fluid and dynamic environment as this is a rapidly evolving space.
- Good understanding of cGMP and GDP requirement and practices.
- Able to don in the cleanroom gowning and understand Aseptic Behavior requirements.

**The Scope**

**Report To**:
**Responsibilities**:

- Work in the CDMO services as a part of the process team to develop processes for downstream unit operations for adherent cells (MSCs, iPSCs, Fibroblast, Epithelial cells, Vero, Hek293t) and derivatives (e.g. exosomes, nanovesicles, viral vectors, secreted viruses, mitochondria) as well as suspension cells for cultivated meat (mainly continuous centrifugation).
- Design, plan, execute, and supervise experimental programs.
- Analyze and interpret experiment data to draw scientific conclusions.
- Perform wet lab and /or clinical trial material activities related to downstream unit operations and associated analytics.
- Support and train subordinates on downstream techniques and operations.
- Author or review protocols, technical reports, technology transfer and training documents with scientifically supported conclusions and recommendations.
- Author or review standard operating procedures, instrument operating procedures and other lab related documents.
- Assess and implement new processes and technologies in development scale, ultimately adapting to manufacturing operations.
- Record and document data promptly and accurately maintaining data integrity.
- Assist in non-routine lab duties and administrative activities including, and not limited to procurement, vendor assessment, people management, equipment maintenance, equipment calibration etc.
- Support validation activities for new equipment as required.

**Requirements**:

- At least 3-5 years’ relevant experience in a life-sciences or related laboratory working with the downstream purification of stem cells/exosomes.
- Experience in filtration (NFF and TFF) unit operations and bioprocess integration.
- Knowledge of protein and molecular analyses, e.g., Western blot, qPCR, ELISA, flow cytometry etc.
- Knowledge of technical or commercial operations in the manufacture of biological molecules is desirable.
- Proficient in MS office
- MS word, MS excel, PowerPoint.
- Take initiatives, self-starter, research oriented, and able to work with minimum supervision.
- Possess good communication and documentation skills.
- Can contribute individually, as well as work efficiently in a dynamic team environment.