Postdoctoral Associate
2 weeks ago
The goal of the project is to identify engineered proteins that can be useful as antimicrobials or as therapies that combat host responses to microbial infections. The approach uses a rational choice of a starting scaffold, informed by manufacturing considerations and a desire to enable non-invasive means of administration. Methods for efficient screening of combinatorial libraries of protein variants will be used, and there is also the oportunity to incorporate machine learning approaches to connect sequence with activity, with the eventual goal of enabling reliable predictive power.
Relevant laboratory skills and experience include:
- applied molecular biology for biomolecular engineering
- protein engineering using yeast surface display
- microbial cell culture (bacteria and yeast)
- next-generation sequencing
- high throughput screening
- flow cytometry
- ELISA
- biolayer interferometry
- knowledge of biomolecular reaction kinetics
- assay development
- statistical analysis of data
**Requirements**:
- PhD in Chemical/Biomolecular/Biological Engineering or related field
- Commitment to reading and synthesizing peer-reviewed and patent literature
- Commitment to publishing peer-reviewed journal articles
- Ability to work well with others
- Careful record keeping
- Strong communication skills (scientific writing and oral presentation)
- Skill in experimental design (systematic studies, informative controls)
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