Scientist Upstream Process Development

5 days ago

Singapore SGVECTOR PTE. LTD. Full time

**Job Description**:

- Perform plasmid cloning, transformation, amplification, and purification.
- Maintain mammalian cell cultures using aseptic techniques.
- Set-up and operate benchtop and large-scale single use bioreactors (50 to 100L)
- Utilize DoE methodology to optimize cell growth and viral vector titers in suspension mammalian cell cultures.
- Collaborate with team members to identify and evaluate process improvements with the goal of optimizing the current rAAV production process.
- Perform molecular biology and analytical assays to support the upstream and downstream PD efforts.
- Draft and edit lab protocols, standard operating procedures, sampling plans, technical documents, and batch records for regulatory or tech transfer purposes.
- Search literature for methods, processes, and assess new equipment and technologies in order to expand and improve upstream AAV capabilities.
- Work with senior team members to perform and understand process experiments and characterization studies.

**Requirements**:

- Master or Bachelor’s degree with ~6 years or more relevant industry experience in Cell and Molecular Biology, Biomedical engineering, Biochemistry, Biotechnology, Chemical Engineering or related fields.
- Considerable direct experience with mammalian cell expression technology and media optimization, utilizing suspension-based bioreactor systems is required.
- Prior experience in viral vector GMP manufacturing, process characterization and QA/QC release testing of viral vector products are required.
- Experience working in a BSL-2 environment and using aseptic techniques.
- Hands-on experience with bench-scale bioreactor operations and large-scale single use bioreactors (50 to 100L) are required.
- Proficient in general molecular biology techniques such as SDS-PAGE, Western blot, flow cytometry, ELISA, ddPCR, qPCR, PCR and cell-based potency assays.
- Experience in drafting study plans, technical reports, and protocols.
- A highly motivated team player with an ability to be productive and a willingness to learn in a fluid, fast-paced and environment are essential.
- Excellent organizational and collaborative skills, with the ability to design and troubleshoot experiments with mínimal supervision or as part of a group.

  • Mammalian Upstream Process Scientist

    5 days ago

    Singapore Lonza Full time

    A global leader in life sciences is seeking an Upstream Process Scientist to join its team in Singapore. You will perform GMP manufacturing operations and maintain high standards in the lab. The ideal candidate holds a degree in a related Science or Engineering field and has knowledge of biopharmaceutical processes. Strong communication and teamwork skills...

  • Upstream Field Applications Scientist, Singapore

    1 week ago

    Singapore Repligen Corporation Full time

    **Overview**: - Repligen is a bioprocessing-focused life sciences company bringing over 30 years of expertise and innovation to our customers. We are inspiring advances in bioprocessing through the development and commercialization of high-value products and flexible solutions that address critical steps in the production of biologic drugs. We are seeking...

  • Upstream Field Applications Scientist, Singapore

    1 week ago

    Singapore Repligen Full time

    Overview: Repligen is a bioprocessing-focused life sciences company bringing over 30 years of expertise and innovation to our customers. We are inspiring advances in bioprocessing through the development and commercialization of high-value products and flexible solutions that address critical steps in the production of biologic drugs. We are seeking a...

  • Upstream Process Scientist

    5 days ago

    Singapore Lonza Full time

    Upstream Process Scientist – Mammalian Manufacturing Today, Lonza is a global leader in life sciences operating across five continents. While we work in science, there's no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people...

  • Intern, Upstream Process Development

    5 days ago

    Singapore Hummingbird Bioscience Pte. Ltd Full time

    **Intern, Upstream Process (USP)**: - Hummingbird Bioscience** (Full-time internship - Singapore based location) **ABOUT HUMMINGBIRD BIOSCIENCE** Hummingbird Bioscience is a data-driven precision biotherapeutics team discovering and developing transformative biologic medicines for hard-to-treat diseases. The Hummingbird Bioscience model combines...

  • Downstream Process Development

    3 days ago

    Singapore NUEVOCOR PTE. LTD. Full time

    **Job description** Nuevocor is a pre-clinical stage biopharmaceutical start-up dedicated to developing gene therapies to treat the underlying cause of genetic cardiomyopathies. Backed by an international syndicate of reputable venture capital firms, it will focus on advancing its lead program to clinical trials. It will also leverage its platform...

  • Senior Process Engineer

    3 days ago

    Singapore Takeda Pharmaceutical Full time

    **Job Title: Senior Process Engineer (Upstream)** **Location: Woodlands, Singapore** **Reporting to: Process Manager** **About the role**: - Lead troubleshooting of manufacturing operations (Upstream/ Downstream) process/product issues - Lead evaluation of new technologies, plan and execute process improvements - Plan and execute global manufacturing...

  • Process Development Scientist

    1 week ago

    Singapore Amgen Inc. (IR) Full time

    Process Development Scientist page is loaded## Process Development Scientistremote type: On Sitelocations: Singapore Manufacturing - Tuastime type: Full timeposted on: Posted Todayjob requisition id: R- ## **Career Category**Process Development## ## **Job Description****Process Development Scientist****Amgen Singapore Manufacturing**Amgen is one of the...

  • Global Procurement Lead: Upstream Processes

    3 days ago

    Central Singapore Asahi Full time

    **Job Description Global Procurement** **Global Procurement Lead: Upstream Processes** **Functional overview** The purpose of Asahi Procurement is to safeguard the existing value and to unlock new sources of sustainable value for Asahi, our customers, and the planet. This is done through partnering with Asahi business stakeholders and a high-performing...

  • Global Procurement Lead: Upstream Processes

    3 days ago

    Singapore ASAHI GLOBAL PROCUREMENT PTE. LTD. Full time

    **Job Description Global Procurement **Global Procurement Lead: Upstream Processes **Functional overview The **purpose **of Asahi Procurement is to safeguard the existing value and to unlock new sources of sustainable value for Asahi, our customers, and the planet. This is done through partnering with Asahi business stakeholders and a high-performing...