Postdoctoral Associate

2 weeks ago

Singapore Singapore-MIT Alliance for Research and Technology Full time

One of the key challenges in deploying cell therapies is the development of analytical assays to ensure their safety for administration. CAMP is developing assays to detect bacterial and viral contaminants, quantify vector copy numbers (VCN), and detect replication-competent lentivirus (RCL) in cell therapy products. This project focuses on innovative technologies for rapid, sensitive, and specific detection and quantification.

The main responsibilities include:

- Lead the development and implementation of VCN, RCL, and adventitious virus detection using CAMP-developed CRISPR/Argonaute-based detection and quantification methods.
- Design, conduct, and validate performance testing of CRISPR/Argonaute-based detection methods using diverse sample sources, including cultured bacteria, viruses, cells, and clinical specimens.
- Collaborate with cross-functional CAMP teammates and the broader Singapore academic and cell manufacturing communities, including engineers, clinicians, GMP manufacturers, and industry partners.
- Prepare and publish research manuscripts based on project findings.
- Maintain comprehensive documentation of protocols, experimental records, and data.

**Job Requirements**:
Ph.D. degree in Bioengineering, Biochemistry, Molecular Biology, Microbiology, Analytical Chemistry, Biotechnology, or a related field.

Experience in nucleic acid detection technologies, CRISPR-based diagnostics, or molecular assay development is highly preferred.

Strong expertise in molecular biology techniques, including PCR, qPCR, digital PCR, and isothermal amplification.

Strong organizational and documentation skills to maintain protocols and data records.

Ability to work collaboratively in an interdisciplinary team.

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