Aav Development Scientist

3 days ago

Singapore GDMC Full time

At Genetic Design and Magic Corporation (GDMC), our mission is to exponentially increase the availability of genetic medicines and change millions of patients' lives. We achieve this by partnering and supporting early-stage companies and investigators with innovative therapeutic modalities such as gene therapies or nucleic acids. Leveraging our expertise in process development and manufacturing, we accelerate our partners ability to bring their ideas through clinical trials and into market. We are growing quickly and looking for talented individuals eager to build something new, challenging and impact lives with transformative medicines.

GDMC is expanding our process development team and is seeking an exceptional AAV development scientist. As a AAV development scientist, you will be involved in developing a robust, well-characterised production process for AAV gene therapy products. You will also be exposed to cutting edge technologies in manufacturing and engineering of AAVs with our partners. If you'd like to play a part in bringing the next life-saving innovations to market, we want you

**Responsibilities**
- Enable execution of discovery and pre-clinical activities through the production of research grade AAV vectors.
- Support development of robust, well-characterised, high quality and high yielding downstream production processes for AAV gene therapy products across internal programs.
- Contribute to the design and execution studies to develop a thorough understanding of the process design space, with a view towards scale-up and successful regulatory filings.
- Oversee and mentor laboratory technicians and interns in proper laboratory techniques and scientific experimental design.
- Engage collaboratively with the client to assess and improve the manufacturability of novel therapeutic modalities.
- Author and follow standard operating procedures, batch records, and other process documentation.
- Filing of invention disclosures and basic understanding of intellectual property with the assistance of relevant internal and external parties/stakeholders.

**Requirements**:

- PhD in molecular biology, virology, synthetic biology or equivalent with 3-5 years of laboratory research experience.
- 1-5 years of work experience with various AAV production platforms or viral vector systems.
- Good understanding of AAV analytics (ddPCR, ELISA, CE-SDS, AUC) in support of product characterisation.
- Innovative and analytical thinker with outstanding interpersonal, communication, and leadership skill.
- Work authorisation in Singapore.

**Salary range**

SGD $6000 - $11000

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