(Senior) Scientist, Analytical Science
2 weeks ago
**Company Background**
**Job Position**
(Senior) Scientist, Analytical Science
- Learn and master the cell therapy production processes and related analytical methods in both scientific knowledge and hands-on skills.
- Understand GMP regulation for manufacturing cell therapies and performing lot release assays and integrate them into approaches for consistent production of high-quality clinical trial materials for Tessa’s early and late phase clinical studies.
- Lead the deep scientific understanding of Tessa’s cell therapy products by designing and conducting in vitro characterization assays and establishing appropriate routine characterization and lot release assays for in-process and final products.
- Independently explore novel _in vitro_ studies to meaningfully assess immunological and mechanism-of-action functions of intermediates and final cell therapy products.
- Develop and qualify assays that will be transferred to the Quality Control group or used for characterization and/or regulatory filing.
- Identify critical quality attributes of the process intermediates, and final products, and perform analytic work for these attributes.
- Establish critical parameters and reagents as well as acceptable operational ranges of the cell therapy products and their in-process materials or critical process steps.
- Collaborate with the in vivo pharmacology and research groups towards a deeper understanding of underlining biology for products and correlation to clinical outcome.
- Perform training and technology transfer of assays across laboratories and sites for cell therapy assays and/or processes.
- Author reports documenting development efforts for product characterization and quality control of cell therapy products, intermediates, and critical reagents.
- Lead the effort in providing characterization product analysis for long-term monitoring of manufacturing processes after technology transfer, work with the production team for troubleshooting efforts, and advice in preventative actions to ensure long-term production success
- Mentoring junior scientists, if required.
**Requirements**:
- MSc/Ph.D. in Immunology or Life Sciences with at least 5-7 years of experience working in developing therapeutic biological drugs; experience with cell therapy and CMC knowledge is highly preferred. Applicants with BSc and extensive experience in developing and qualifying analytical lot release assays will also be considered.
- Strong understanding of the immune system and dysregulation and excellent hands-on skills in various immune research techniques (Flow, ELISA, and ELISPOT assays), **AND/OR**:
- Technical and hands-on experience in developing genetic and genomic assays for product release and characterization, i.e., RCR qPCR assays, Viral Copy Number assays using ddPCR, and experience with NGS sequencing methods and analysis.
- Knowledge and experience working with viral vectors and characterization.
- Strong analytical skills and good scientific writing and presentation skills.
- Good problem-solving and communication skills
- Highly self-motivated and a good team player
- Experience with statistical analysis using JMP, Prism, and setting up DOE studies will be highly preferred.
- Ability to work well under pressure and challenging timelines.
-
Singapore HTX (Home Team Science & Technology Agency) Full timeJoin to apply for the Data Scientist/Senior Data Scientist, Risk Sensemaking Analytics, xData role at HTX (Home Team Science & Technology Agency). What The Role Is As a Data Scientist (Risk Sensemaking Analytics) in HTX, you will develop a suite of in‐house AI models to augment the cognitive workload of Home Team officers, and collaborate with stakeholders...
-
Data Scientist/Senior Data Scientist
7 days ago
Singapore HTX (Home Team Science & Technology Agency) Full timeJoin to apply for the Data Scientist/Senior Data Scientist (Optimisation), Decision Science, xData role at HTX (Home Team Science & Technology Agency). What The Role Is At HTX, our vision is to exponentially impact Singapore's safety and security, ensuring a safer and more resilient future for all. Our mission drives us towards force multiplying our Home...
-
(Senior) Scientist, Process Sciences
2 weeks ago
Singapore Tessa Therapeutics Pte Ltd Full time**Company Background** Tessa Therapeutics is a clinical-stage biotechnology company developing a portfolio of next-generation cell therapies for cancer. It has a pipeline of therapies in clinical development for the treatment of hematological malignancies and solid tumors. Tessa’s lead autologous therapy is in late-stage clinical development for...
-
Scientist, Human Development Group
2 weeks ago
Singapore A*STAR - Agency for Science, Technology and Research Full timeOverview The focus of the A*STAR Institute for Human Development and Potential (A*STAR IHDP) is research to improve the health and well-being of Singaporeans across the life course. We are seeking an enthusiastic and capable full-time Postdoctoral Fellow for the project at A*STAR IHDP. The candidate should have expertise in family, children and youth...
-
Scientist / Senior Scientist I (NQFF), IMRE
2 weeks ago
Singapore A*STAR - Agency for Science, Technology and Research Full timeJoin to apply for the Scientist / Senior Scientist I (NQFF), IMRE role at A*STAR - Agency for Science, Technology and Research The National Quantum Federated Foundry (NQFF) is advancing the frontiers of solid-state quantum technologies through the design and fabrication of high-performance quantum devices. We are seeking a motivated and capable candidate to...
-
Senior/ Research Officer
7 days ago
Singapore NodeFlair Full time**Job Summary**: **Salary** S$3,725 - S$7,450 / Monthly EST **Job Type** **Seniority** Senior **Years of Experience** Information not provided **Tech Stacks** C++ Analytics R Java PythonWe are looking for highly motivated and skilled data scientist/AI engineer to work on a new initiative to develop modelling of mammalian and microbial cell cultures. The...
-
Senior/ Research Officer
7 days ago
Singapore NodeFlair Full time**Job Summary**: **Salary** S$3,000 - S$6,000 / Monthly **Job Type** **Seniority** Senior **Years of Experience** At least 2 years **Tech Stacks** C++ Analytics R Java Python We are looking for highly motivated and skilled data scientist/AI engineer to work on a new initiative to develop modelling of mammalian and microbial cell cultures. The work will...
-
Senior Forensic Scientist
1 week ago
Singapore HTX (Home Team Science & Technology Agency) Full timeDescription Senior Forensic Scientist (Chemistry), Forensics COE Join the Home Team Science & Technology Agency (HTX) as a Senior Forensic Scientist in the Chemistry team. In this pivotal role you will champion cutting‑edge research in forensic chemistry to support investigation and intelligence for the Home Team Departments. What you will be working on...
-
Senior Forensic Scientist
1 week ago
Singapore HTX (Home Team Science & Technology Agency) Full timeDescription Senior Forensic Scientist (Chemistry), Forensics COE Join the Home Team Science & Technology Agency (HTX) as a Senior Forensic Scientist in the Chemistry team. In this pivotal role you will champion cutting‐edge research in forensic chemistry to support investigation and intelligence for the Home Team Departments. What you will be working on...
-
Scientist/senior Scientist, Ai, Artc
2 weeks ago
Singapore A*STAR Agency for Science, Technology and Research Full timeThe Smart Remanufacturing Systems Group is looking for a Scientist/Senior Scientist with related research experience in machine vision and artificial intelligence. In this role, you will be responsible for driving the group's research in the area of product disassembly automation via machine vision and artificial intelligence. Job Description &...
