
Senior Analytical Scientist/ Principal Analytical Scientist
1 day ago
**Site Name**: Singapore - Jurong
**Posted Date**: May 7 2025
**Purpose**:
We are looking to fill a new Analytical Scientist position in the GSK Global Manufacturing Science and Technology (MSAT) Analytical Science Asia Hub as part of our expanded remit to support GSK Vaccines. As an Analytical Scientist in the Asia Hub, you are part of the Global Analytical Science team encompassing analytical scientists and materials science experts all over the world covering 3 modalities (small molecule, large molecule and vaccines) in the Global Supply Chain (GSC). In this role, you will focus on leading/ supporting the set-up and qualification of a state-of-the art analytical laboratory and implementation of cutting-edge, advanced analytical technologies for vaccines drug substances and intermediates from pre-launch to late product lifecycle, with potential opportunities to flex, learn and impact across different parts of the business.
**Key Responsibilities**:
- ** Analytical Leadership and Innovation**: Spearhead the full spectrum of analytical activities, including setting up advanced equipment, analytical method technology transfer and optimization, non-routine characterization and comparability assessments of drug substances and intermediates to support new and established vaccines products. These include providing matrix leadership, leading and presenting characterization programs, projects and results to global stakeholders/ partners.
- ** Data-Driven Insights and Recommendations**: Pro-actively generate and interpret comparability data of drug substances/ intermediates as part of material and process changes/ improvements to drive high impact, data-driven recommendations for the optimization of manufacturing processes to improve right first-time performance, product quality, robustness, cost savings and manufacturability.
- ** Problem-Solving and Root Cause Analysis**:Lead laboratory investigations and trouble-shooting related to analytical equipment, methods and out-of-trend results, ensuring timely resolution with effective corrective and preventive actions to minimize business impact and keep projects on track. Provide prompt analytical support for process deviations to minimize impact on security of supply.
- ** Development of Robust Analytical Strategies**: Review and improve analytical methods, procedures and standards in accordance with pharmacopoeia requirements and in-house analytical technical standards, ensuring robust analytical method performance throughout the product lifecycle for both new and established products.
- ** Analytical Equipment Stewardship**: Qualification and lifecycle maintenance (including preventive maintenance/ calibration and performance verification checks) of cutting-edge analytical equipment to appropriate analytical standards aligned with data criticality. Ensure robustness and reliability of analytical equipment in line with GMP and data management principles, mitigating data integrity risks.
- ** Lifecycle Data Management**: Ensure thorough, complete and accurate documentation of all laboratory procedures and data, including standard operating procedures, work instructions, protocols, reports, laboratory notebooks, technical memos, raw data and risk assessments. Maintain compliance to GMP and GLP requirements ensuring data traceability and easy retrieval.
- ** Champion for Laboratory Safety and Sustainability**: Lead/ support environmental health, safety and sustainability activities for the laboratory. Ensure a safe laboratory working environment and inspection readiness of the laboratory through management monitoring (MM)/ independent business monitoring (IBM) inspections, regular safety GEMBA(s) and risk assessments for all analytical activities carried out.
- ** Mentorship and Development**: Supervise, train and develop interns and junior scientists, fostering a culture of safety, compliance and excellence in laboratory practices and data generation.
**Skills, Knowledge and Experience**:
- At least a degree in Pharmacy, Chemistry, Pharmaceutical Sciences, Biochemistry/ Biotechnology, Biomedical Engineering or equivalent.
- Extensive hands-on experience in an analytical environment, preferably in the pharmaceutical industry with understanding of GMP and GLP requirements or equivalent.
- Prior experience (min 5 years) in analytical technologies for the analysis and characterization of biologics or vaccines is required.
- Experience in small molecules or material science analytics or an interest in learning more about these is a plus.
- Hands-on experience, skilled in the execution, optimization and trouble-shooting in one or more of the following analytical techniques is preferred: Chromatographic techniques (ultra-performance liquid chromatography with charged aerosol detection, size-exclusion chromatography with multi-angle light scattering, gas chromatography), chemiluminesence techniques, analysis of biomolecular interactions by bio-layer interferometry, fluore
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