Scientist

6 days ago

Singapore MSD Full time

**Scientist**
- Opportunity to **be a part of the Research Scientist Team**:

- ** Based in Singapore**, the regional hub for Asia Pacific (AP) and top-ranked biopharmaceutical company on The Straits Times and Statista’s list of Best Employers in Singapore for two consecutive years (2020, 2021).
- Join the **premier biopharmaceutical company** that has been in Singapore for more than **25 years and in AP for over 60 years.**

Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough.

The Genome & Biomarker Sciences (GBx) department is currently seeking a Scientist with strong experience in bioanalytical assay development to join our Molecular Biomarkers team at the Singapore site. In this role, you will be accountable for developing, validating, and deploying biomarker assays on Cardio-Metabolic Disease (CMD) and Neuroscience (NS) projects, using samples from animal models and patients, with the goal of driving patient stratification, demonstrating target engagement, evaluating pharmacodynamic response, and guiding dose selection.

In Singapore, our site is located within the Biopolis, the heart of Singapore’s biomedical research community. Here, we are focused on identifying and validating new drug targets, exploring innovative therapeutic modalities, and leveraging clinical studies and patient-derived material to understand biomarkers of disease or therapeutic response. Our state-of-the-art laboratory supports discovery biology and translational medicine and is an integral part of the company’s world-class network for drug and vaccine discovery.

Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities, and robust scientific methodology we collaborate to discover the next medical breakthrough.

**WHAT YOU WILL DO**

**Primary Responsibilities**
- Develop and execute robust bioanalytical assays to support cell-based, in vitro, and in vivo studies.
- Work closely with Discovery Biology, In Vivo Pharmacology and Translational Medicine teams to support biomarker studies.
- Work with limited supervision on experimental design, troubleshooting, assay optimization and data interpretation.
- Make detailed observations, analyze data, interpret results, and exercise appropriate technical discretion in the design and execution of experiments.
- Participate in and communicate the interpretation of research results in cross-functional team meetings.
- Coordinate preventive maintenance for laboratory equipment, troubleshoot equipment malfunction, and support the team in routine operational activities for the laboratory
- Assist in training personnel in the operation of laboratory equipment as needed.
- Keep up to date with emerging biomarker technology platforms and evaluate their utility in providing novel insights into disease biology.
- Accurately document experiments and results in electronic notebooks and/or other required formats in compliance with company policies and project needs.

**WHAT YOU MUST HAVE**

To be successful in this role, you will have:
**Education Minimum Requirement**:
M.Sc in analytical chemistry, biochemistry, or equivalent, with 5+ years or B.Sc with 7+ years’ experience working in a bioanalytical or a quality control (QC) laboratory, preferably at an biotechnology or biopharmaceutical company.

**Required Experience and Skills**:

- Hands-on experience with the design, development, optimization, qualification, and validation of novel bioassays and immunoassays using multiple platforms and technologies (e.g., ELISA, MSD/Luminex, flow cytometry, cytokine analyses, and cell-based reporter and cytotoxicity assays).
- Experience with protein analytical methods (e.g., SDS-PAGE, Western Blotting).
- Experience with genomic and transcriptomic methods (e.g., RNA extraction, qPCR, RNA-seq)
- Experience with sample processing methods to support protein and nucleic acid detection from a variety of tissue types.
- Track record of developing technical methods and SOPs.
- Experience working in a GxP environment, and CRO management for method transfer will be an added advantage
- Strong problem solving and troubleshooting skills.
- Excellent interpersonal and verbal/written communication skills.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can s

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