Research Fellow

4 days ago

Novena, Singapore Nanyang Technological University Full time

This Research Fellow position will play a critical role in the synthesis, purification, and characterization of proprietary chemical compounds for preclinical animal studies. In addition, this role will be actively involved in pharmacokinetics studies to evaluate compound bioavailability, metabolism, and systemic distribution. The Research Fellow will also contribute to scientific communication, project coordination, and intellectual property development.

Key Responsibilities:
1. Chemical Synthesis and Purification
- Design and execute synthetic strategies to produce proprietary chemical compounds with high purity and yield.
- Optimize reaction conditions and purification techniques, including chromatography and crystallization.
- Characterize synthesized compounds using analytical techniques such as NMR, mass spectrometry, HPLC, and LC-MS.
- Maintain detailed documentation of synthetic protocols, compound properties, and experimental observations.

2. Pharmacokinetics and Preclinical Studies
- Conduct pharmacokinetic (PK) studies to assess compound absorption, distribution, metabolism, and excretion (ADME).
- Prepare and analyze biological samples using LC-MS/MS and other relevant techniques.
- Collaborate with in vivo research teams to design and implement dosing regimens for animal experiments.
- Interpret PK data and contribute to the optimization of compound formulations for improved bioavailability.

3. Scientific and Collaborative Coordination
- Organize and facilitate regular meetings with lab members to discuss research progress and troubleshoot experimental challenges.
- Coordinate collaborative efforts with internal and external research partners, ensuring smooth information flow and project alignment.
- Assist in managing research timelines, experimental priorities, and resource allocation for ongoing studies.

4. Manuscript and Patent Drafting
- Lead and contribute to manuscript preparation, ensuring high-quality scientific writing for journal submissions.
- Conduct literature reviews to support manuscript and patent development, positioning findings within the broader scientific landscape.

5. Laboratory and Compliance Management
- Ensure adherence to safety protocols and regulatory guidelines for chemical synthesis and animal experimentation.
- Maintain laboratory inventory, including reagents, solvents, and analytical consumables.
- Train and mentor junior researchers and students in chemical synthesis techniques and analytical methodologies.

Key Requirements:

- Ph.D. in Organic Chemistry, Medicinal Chemistry, Pharmacology, or a related field.
- Strong expertise in organic synthesis, purification, and compound characterization techniques.
- Experience with pharmacokinetics studies and analytical methods such as LC-MS.
- Excellent scientific writing skills for publications and patents.
- Strong organizational and project management abilities.
- Ability to work independently while collaborating effectively with multidisciplinary teams.

Hiring Institution: LKC

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