Head of Msat

**Site Name**: Singapore - Tuas
**Posted Date**: Feb 27 2025
**_ Purpose_**:
The Head of Manufacturing Science & Technology (MSAT) at the GSK Tuas Site is a key leadership role responsible for defining and executing the vision and strategy for the MSAT organization. This role ensures successful manufacturing support for both commercial and clinical operations, oversees process and equipment validations to meet global standards, and drives continuous process improvements for drug substance production and supply. Additionally, the Head of MSAT manages the lifecycle of registered products and spearheads the introduction of new products and technologies, ensuring they comply with regulatory requirements.

The Head of MSAT works closely with various departments such as Quality, Regulatory, and Manufacturing to ensure seamless technology transfer and ongoing manufacturing for both clinical and commercial pipelines. This position requires strong leadership to guide a team of Managers, Scientists, Experts, and Engineers, providing direction and support to achieve the organization’s goals. The role directly reports to the GSK Tuas Site Director and has a dotted line reporting to the Vice President of MSAT Vaccines.

Overall, the Head of MSAT is accountable for managing site manufacturing support, developing and delivering the site’s new product introduction roadmap, and overseeing the lifecycle management of registered products. This position is critical for ensuring that GSK's vaccines are manufactured efficiently, meet regulatory standards, and are supplied globally, thereby supporting GSK's strategic objectives and long-term success.

**_ Key Responsibilities Area_**:
**Manufacturing Support**:

- Provide technical support to the cGMP manufacturing operation.
- Ensure manufacturing processes are robust and all site products remain validated throughout the product lifecycle.
- Analyze operations for potential improvement opportunities and recommend changes.
- Develop recommendations for change in conjunction with management and staff to leverage their operational expertise.
- Design processes to optimize flow, reduce variability, improve capability, and enhance employee safety.
- Ensure process techniques align with corporate goals and quality policy.
- Provide technical leadership in investigating delivery system failures and implementing corrective and preventive actions.

**Product life cycle management**:

- Strategize the entire product lifecycle
- Manage GMP manufacturing of drug substances for development and commercial products.
- Plan data-driven projects to enhance process robustness and continuous monitoring.
- Ensure the site can conduct Product Robustness and risk assessments, and address gaps.
- Support the product lifecycle with material changes and cost reduction initiatives.
- Develop technical reports for process validation, stability, and comparability.
- Suggest ways to increase yield, capacity, and reduce costs while staying compliant.
- Identify and propose process improvements with various teams.

**New product launches and technology transfers**:

- Represent the site on the new product committee, set project priorities, and allocate MSAT resources.
- Oversee technology transfer, outsourcing, and manufacturing to maintain a robust, compliant, and cost-effective supply chain.
- Lead the team for technology transfer of drug substances and products.
- Develop and manage Technology Transfer and Manufacturing teams, including external contractors.
- Engage with Global MSAT Process Science and site resources for new product readiness.
- Work with Global MSAT Process Science to commercialize new products.
- Ensure sites can scale up and validate new products.
- Plan and execute product transfers from other sites.

**Product strategy and site registration**:

- Develop regulatory strategies to ensure product quality and global approvals, and improve supply chain flexibility.
- Align operational focus and long-term strategy with Global MSAT Process Science and company goals.
- Manage dependencies and priorities across GSK for consistent product delivery.
- Use data to set success metrics, prioritize needs, and communicate plans and progress.
- Oversee development projects from early to commercial stages of biologics.
- Collaborate with Business Development and Manufacturing Strategy to find new opportunities and partners.
- Support regulatory filings and inspections from agencies like FDA and EMA.

**Organization and team**management/development**:

- Foster an inclusive workplace, staff development, innovation, quality culture, safety, and high performance.
- Lead the MSAT team to achieve site goals and provide process support in compliance with cGMP.
- Promote a science-based, motivated, and accountable culture focused on innovation and quality.
- Contribute to the Site Leadership Team in setting site strategy and goals.
- Develop and manage department budgets.
- Position the department for future