Lead Scientist

Join us for the world we are making, redefining biosolutions for current and future generations to come, transcending planetary boundaries, sustainability, and One Health.

The Opportunity

Esco Lifesciences Group is Singapore's most globalized life sciences company, with annual revenues close to SGD 200M and global operations in over 42 locations and 26 direct countries across North America, Europe, Asia, Oceania.

Esco Aster Pte Ltd is an affiliate of Esco Lifesciences Group and was first incorporated in 2017. Esco Aster is a contract research development and manufacturing organization founded and deeply rooted by scientists enabling fellow scientists to translate their bench work into commercially available products at affordable prices.

Our scientific work is in emerging and frontier biology utilizing cells as a final product or deriving products from cells which often we use cells as the factory to derive our target product.

Our first commercial breakthrough success is Esco Aster is commercially first in class being first in the world to be certified for cultivated/cell-based meat to FSSC 22000 and by a competent food regulatory body.

We are first in the region to operate an end-to-end integrated full cell line creation/immortalization or engineered cell line, cell culture process development, analytical development for stem cells and exosomes with full cGMP Capabilities from Drug Substance and small-scale fill & finish for final Cell Therapy Product.

The work we do creates a remarkable and lasting impact on our world. We offer you an opportunity to be part of this exciting journey to own your career and firsthand exposure to new emerging modalities supporting translational sciences.

Join us as we redefine BioSolutions for One World and One Health for the current and future generations to come.

Who we're looking for

• Ability to read, analyze and interpret scientific data and publications.
• Ability to author or review protocols, technical reports and technology transfer documents.
• Ability to author or review standard operating procedures and other related documents.
• Ability to define problems, collect data, establish facts, and draw conclusions.
• Ability to focus.
• Repetitive motions due to certain laboratory techniques.

The Scope

You will be part of Esco Aster's Cell Line Creation division and contribute to the company's CDMO mission and objectives. You will plan and execute experiments in support of the cell line generation division and generate high productivity mammalian cell lines and execute the diverse cell culture experiments required to produce various vaccine candidates and antibodies, in collaboration with internal and external stakeholders, clients and partners.

Primary work location: Ayer Rajah, Singapore.

Reports to: Head of Scientific & Sales Operations.

Job Responsibilities

• Perform key activities associated with cell line development including molecular cloning, in vitro transcription, transfection, Single cell cloning, clone selection, characterization and cell banking.
• Perform tasks in a compliant manner according to SOP guidelines and regulations.
• Write technical reports and campaign summaries.
• Prepare solutions and culture media (small scale as well as large scale).
• Perform analysis of cell metabolites, medium components etc. by Bioanalysis.
• Maintain accurate batch records and results following good manufacturing practices (GMP).
• Work independently and efficiently.
• Document work clearly and perform tests accurately.
• Communicate effectively with client staff members and provide updates on the progress of the project.
• Liaise with vendors and third-party testing labs to procure materials and obtain test results in a timely manner.

Requirements

• At least 1-2 years related laboratory experience including aseptic and mammalian cell culture techniques.
• Microbiology/Cell biology Background.
• Experience with bioreactor systems.
• Good troubleshooting ability with cell lines.
• General laboratory skills, good pipetting skills and experience with automation.
• Experience using formulas and linking spreadsheets in Excel.
• Strong computer, scientific, and organizational skills.
• Excellent communication (oral and written) and attention to detail.
• Ability to work independently and as part of a team, self-motivation, adaptability, and a positive attitude.
• Ability to learn new techniques, perform multiple tasks simultaneously, keep accurate records, follow instructions, and comply with company policies.
• A friendly and pleasant disposition.
• Masters in Biology or related science and 1-2 Years Mammalian Cell Culture experience.