Scientist, target biology
13 hours ago
Job Description At our company, we are committed to becoming the premier research-intensive biopharmaceutical company and are dedicated to providing leading innovations and solutions for today and the future. Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to identify agents that are effective in treating or preventing human disease and to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities, and robust scientific methodology we collaborate to discover the next medical breakthrough. We are seeking a Scientist to join our Target Biology & Screening team at our research laboratory in Singapore. Our team focuses on active collaboration with cross-functional groups to design, develop and drive fit-for-purpose high-throughput screening assays to support the development of multiple therapeutic modalities across various disease areas and therapeutic indications. We are passionate about developing novel, translationally relevant assays, applying automation strategies to drive programs from target validation through lead optimization, particularly in disease areas with critical unmet needs, and to accelerate the discovery and development of new drugs. As a Scientist, you are expected to possess good knowledge in molecular and cell biology, with experience in cell culture, research operations, laboratory management, and data analysis skills. You will work as part of a cross-functional team driving early drug discovery programs across multiple target classes, modalities, and therapeutic areas. You will be responsible for optimizing, executing, and validating biochemical and cell-based assays according to industry standards to drive drug screening programs. You are expected to have hands-on experience in a variety of basic laboratory skills, applying an understanding of underlying biological mechanisms and assay principles to develop fit-for-purpose in vitro / ex vivo assays. Additionally, you will have the opportunity to learn from industry experts, gain exposure to a research-driven enterprise and utilize your passion, creativity, knowledge, and collaboration skills to find solutions to challenging scientific problems. What You Will Do: Responsibilities include, but are not limited to: Support the development, optimization, and validation of in vitro biochemical, molecular, cellular assays for target validation and hit finding studies across diverse therapeutic diseases and modalities by performing wet lab experiments as needed. Support drug discovery and lead optimization programs by delivering and executing on robust, quantitative screening assays and analyzing screening data to support the development of data packages to enable pipeline advancements. Perform routine and non-routine assay screening, applying effective organization, time management, and prioritization to deliver data within defined cycle times. Participate in team meetings and contribute to discussions on project progress and findings. Present research findings to drug discovery teams and take ownership of data generated. Support the development of induced pluripotent stem cell (i PSCs) lines and mammalian cell lines by performing routine cell culture maintenance to enable development of robust assay-ready cells for high-throughput drug screens. Collaborate broadly to develop simplified, efficient assay management workflows to drive discovery programs with higher efficiency and productivity. Develop and implement compound plating workflows and compound inventory and management strategies to support efficient handling and organization of compound libraries, including ordering requests. Serve as the primary point of contact for compound inventory and management for the site. Develop, implement, and troubleshoot assay automation protocols to enable robust and high-throughput studies for disease profiling and compound screens. Work in collaboration with data analytic groups to build reliable pipelines for quantitative data analysis, including participation in software upgrading activities. Maintain data integrity and compliance by taking ownership of the data lifecycle, perform accurate experimental record-keeping, and author documentation including SOPs, assay long protocols, research reports, and data presentations in collaboration with team members. Support and participate in various lab management and environment, health, safety initiatives as needed, including performing regular purchasing of laboratory reagents and supplies, basic maintenance and quality control of equipment, and serving as the primary point of contact for equipment troubleshooting. What You Must Have: To be successful in this role, you will have: Masters in Cell Biology/Biochemistry/Pharmacology, MSc in a Life Science-related discipline with more than five years of relevant research experience or BSc with a minimum of 8 years of relevant experience in automation and in vitro high-throughput screens and assay development. Some experience executing and validating in vitro biophysical, biochemical, molecular, cellular assays using a wide range of modern technologies and detection methods. Good track record in assay development, optimization, and troubleshooting. Experience with inventory management of samples or compounds using database software. Experience developing robust automation protocols for high-throughput drug screens using state-of-art liquid handling platforms such as ECHO, BRAVO, Tecan, etc. is a plus. Good working knowledge and hands-on experience in cell culture and bio sample preparation, including 2 D mammalian cell lines. Experience working with i PSC-derived models, primary cell culture, and 3 D organotypic cultures is a plus. Good understanding of cell biology and molecular biology is preferred. Good organizational, troubleshooting skills and knowledge in pharmacological data analysis is preferred. Collaborative and independent scientist that excels in a matrix environment. Possess the ability to multitask, prioritize work, attention to detail and work effectively as part of a team in a fast-paced dynamic environment. Willingness to learn new techniques and adapt to changing priorities. Possess a positive, proactive attitude and embodies a growth mindset. What You Can Expect: Opportunity to work at the interface of multiple disciplines and integrate cutting-edge science, novel methodologies into drug discovery research. Collaboration with interdisciplinary teams to learn from each other, apply your innovative mindset to experiment with new ideas and approaches and drive the development of state-of-art technologies. A supportive working environment that fosters career growth, continuous learning, and diversity, equity, and inclusion. #J-18808-Ljbffr
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