Biotechnologist (Upstream)

3 days ago

Singapore Tek Systems Full time

Bioreactor Operations
Media and Reagent Preparation
Cell Banking & Subculturing
Role Summary
We are looking for a motivated Biotechnologist, you will execute routine and critical manufacturing operations within the Cell Culture (upstream) area, ensuring consistent production of clinical and/or commercial biologics. You will operate and maintain bioreactors and related equipment in compliance with GMP guidelines and SOPs, contributing to process reliability and product quality.
Key Responsibilities
Bioreactor Operations:
Prepare, set up, and operate single-use and stainless-steel bioreactors (from 50 L to 2 000 L scale).
Monitor and adjust culture parameters (pH, DO, temperature, agitation) to maintain optimal cell growth.
Media and Reagent Preparation:
Formulate and sterilize culture media, feed solutions, and buffers.
Perform buffer exchanges and feed additions according to batch protocols.
Cell Banking & Subculturing:
Thaw, expand, and maintain working and master cell banks under sterile conditions.
Conduct viability and sterility checks (trypan blue exclusion, microscopic inspection).
Sampling & In-Process Testing:
Collect and process samples for cell density, viability, metabolite, and metabolomic analyses.
Document results accurately in electronic batch records.
Equipment Cleaning & Sterilization:
Execute CIP/SIP procedures on reactors, tubing, and ancillary equipment.
Maintain cleanroom attire discipline and adhere to gowning/ungowning protocols.
Documentation & Compliance:
Follow SOPs, batch records, and deviation/incident reporting processes.
Participate in periodic audits, investigations, and continuous improvement initiatives.
Cross-Functional Support:
Collaborate with Purification, Quality, and Engineering teams to troubleshoot process deviations.
Assist in scale-up activities and technology

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