Postdoctoral Research Fellow in Computational Biophysics

4 days ago


Singapore NANYANG TECHNOLOGICAL UNIVERSITY Full time
Job Summary

We are seeking a highly skilled Postdoctoral Research Fellow to join our team at Nanyang Technological University (NTU). This is a two-year postdoctoral research and studies position that will bring outstanding young researchers, who have graduated from a Swedish university, to NTU.

About the Role

The successful candidate will conduct molecular dynamics simulations to investigate conformational changes and dynamics of specific proteins. Utilizing machine learning-driven structure prediction, they will model and validate potential protein conformations. They will also analyze free energy landscapes to understand the stability and equilibrium of protein conformations during activation processes.

The ideal candidate will apply structure-based virtual screening using deep learning frameworks to identify and evaluate new small-molecule targeting specific drug targets. Conducting molecular docking and free energy calculations, they will predict binding affinity and efficacy of potential binders. Additionally, they will collaborate with experimental biologists to validate computational predictions through site-directed mutagenesis and other biochemical assays. Finally, they will work with medicinal chemists to optimize lead compounds for better affinity, potency, and drug-like properties.

Requirements
  • A Ph.D. degree related to computational biophysics, molecular biology, bioinformatics, or computational chemistry.
  • Strong computational skills, including molecular dynamics simulations, machine learning-driven structure prediction, and enhanced sampling techniques.
  • Skill in using computational software such as GROMACS and AMBER simulations; proficiency in programming languages like Python for data analysis and machine learning.
  • Good knowledge in computational biophysics, molecular biology, biochemistry, and drug discovery.
  • Demonstrated ability to work collaboratively with structural biologists, medicinal chemists, and experimental biologists.
  • Excellent written and oral communication skills for documenting research findings, preparing reports, and presenting results to diverse audiences.
Benefits

This is an exciting opportunity for an ambitious researcher to contribute to cutting-edge research projects and advance their career in computational biophysics. The salary range for this position is SGD $90,000 - $110,000 per annum, commensurate with experience. We regret that only shortlisted candidates will be notified.



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