Senior Postdoctoral Scientist

2 weeks ago

Singapore beBeeResearch Full time
Job Title: Postdoctoral Research Scientist

The laboratory of Professor Giorgia Pastorin at the National University of Singapore (NUS) is currently recruiting a postdoctoral research scientist.

We are seeking for a highly motivated and competent researcher to work on a funded research project aimed at deciphering the roles of MOAP-1 in cellular senescence and ageing-associated disorders in liver.

The long term goal of the project is to gain novel insights towards developing viable approaches for mitigating development and progression of liver NAFLD-associated liver diseases including MASH and HCC, as well as developing novel nanoformulations that enhance the accumulation of actives at the disease site.

Successful candidate will have the opportunity to work with a multidisciplinary team as well as collaborators in Singapore and overseas.

To facilitate a better understanding of the work being pursued in the laboratory, prospective applicants can refer to the following papers:

  • K.O. Tan et al., MAP-1 is a mitochondrial effector of Bax, Proc. Natl. Acad. Sci., USA, 2005.
,
  • N.Y. Fu et al., Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria, Proc. Natl. Acad. Sci., USA, 2007.
,
  • S.K. Sukumaran et al., A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to inhibit host cell apoptosis, Molecular Cell, 2010.
,
  • C.T. Tan et al., MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria, Cell Reports, 2016.
,
  • H.C. Chang et al., The BAX-binding protein MOAP1 associates with LC3 and promotes closure of the phagophore, Autophagy,

Responsibilities include:

Key Responsibilities:

  • Planning and execution of experiments.
  • Collection and analysis of research data.
  • Guiding and working with junior staffs, including graduate/undergraduate students.
  • Participation in preparation of manuscripts and other reports.
  • Uphold research integrity and ensure safety compliance.
Interested candidates please submit a detailed curriculum vitae, contact information of 3 referees and indicate your earliest availability.

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