Research Fellow
2 weeks ago
The successful candidate will work with Prof YAO Shao Qin on chemical biology/drug discovery-related research under a project on 'A Paradigm Shift in Kinase Drug Discovery - Development of Lysine-Targeting, Cell-Active Covalent Inhibitors (CIs) with High Potency and Selectivity (MOE T2)'.
Human kinases and epigenetic proteins are important therapeutic targets. Recent development of selective and potent inhibitors of proteins has yielded remarkable results in disease treatment, with numerous drugs already on the market, and many more undergoing clinical trials. Notwithstanding, the discovery of new covalent kinase and epigenetic drugs remains highly challenging, including issues related to selectivity, ecacy and acquired drug resistance. Taking cue from the kinase drug discovery field, the hypothesis of these projects is that a universal strategy for targeted covalent inhibitors (TCIs) capable of potent target inhibition and minimal acquired drug resistance is possible, if highly effective small molecules could be developed to covalently target non-cysteine (C) nucleophilic residues within/near the active-site of kinase/epigenetic proteins. Our recent discovery of covalent kinase inhibitors against BCR-ABL (a key kinase for CML) in which CBA/SA and EBA warheads formed stable, (reversible and irreversible) covalent linkage with catalytic lysine (K) in Abl kinase under cellular environments indicates other covalent chemistries are feasible. Therefore, the goal of the current proposals is to confirm covalent chemistries targeting other nucleophilic residues (E/D/R/M/etc) are possible, and amenable to the development of cell-active, selective TCIs for various therapeutic proteins.
The scope of this proposal will be limited to the fundamental basic science, and NOT the actual clinical implementation, of the developed chemical/chemical biology tools. Therefore, only cell-based and basic animal models will be tested on newly developed, select small-molecule TCIs. Experience/skills required are organic synthesis/chemical biology/protein chemistry/proteomics/molecular biology/cell biology (only some of above skills are required)
Qualifications- Qualifications / Discipline: PhD or equivalent in Chemistry/Biochemistry/Pharmaceutical Chemistry/Biology
- Skills: Organic synthesis/chemical biology/protein chemistry/proteomics/molecular biology/cell biology
- Experience: Fresh PhD graduates or PhD holders with < 5 years of experience in any/some of above fields
Department : Chemistry
Employee Referral Eligible: No
Job requisition ID : 23429
-
Research Fellow/Research Scientist
3 days ago
Singapore A*star Research Entities Full timeWe are seeking to recruit a highly motivated Research Fellow/Research Scientist to support the institute's overall Research and Innovation goals.Job Description:The Research Fellow/Research Scientist will be responsible for engineering novel CAR-NK cells with superior anti-tumor efficacy, enhanced tumor infiltration, and excellent resilience against the...
-
Research Fellow/Research Scientist
3 days ago
Singapore A*star Research Entities Full timeWe are seeking to recruit a highly motivated Research Fellow/Research Scientist to support the institute's overall Research and Innovation goals.Job Description:The Research Fellow/Research Scientist will be responsible for engineering novel CAR-NK cells with superior anti-tumor efficacy, enhanced tumor infiltration, and excellent resilience against the...
-
Research Fellow/Research Scientist
3 days ago
Singapore A*star Research Entities Full timeWe are seeking to recruit a highly motivated Research Fellow/Research Scientist to support the institute's overall Research and Innovation goals.Job Description:The Research Fellow/Research Scientist will be responsible for engineering novel CAR-NK cells with superior anti-tumor efficacy, enhanced tumor infiltration, and excellent resilience against the...
-
Research Fellow/Research Scientist
3 days ago
Singapore A*star Research Entities Full timeWe are seeking to recruit a highly motivated Research Fellow/Research Scientist to support the institute's overall Research and Innovation goals.Job Description:The Research Fellow/Research Scientist will be responsible for engineering novel CAR-NK cells with superior anti-tumor efficacy, enhanced tumor infiltration, and excellent resilience against the...
-
Research Fellow/Research Scientist
3 days ago
Singapore Agency for Science, Technology and Research (A*STAR) Full timeWe are seeking to recruit a highly motivated Research Fellow/Research Scientist to support the institutes overall Research and Innovation goals.Job Description:The Research Fellow/Research Scientist will be responsible for engineering novel CAR-NK cells with superior anti-tumor efficacy, enhanced tumor infiltration, and excellent resilience against the...
-
Research Fellow/Research Scientist
Found in: Talent SG 2A C2 - 20 hours ago
Singapore A*STAR RESEARCH ENTITIES Full timeRoles & ResponsibilitiesWe are seeking to recruit a highly motivated Research Fellow/Research Scientist to support the institute’s overall Research and Innovation goals.Job Description:The Research Fellow/Research Scientist will be responsible for engineering novel CAR-NK cells with superior anti-tumor efficacy, enhanced tumor infiltration, and excellent...
-
Research Fellow/Research Scientist
3 days ago
Singapore Agency for Science, Technology and Research (A*STAR) Full timeWe are seeking to recruit a highly motivated Research Fellow/Research Scientist to support the institutes overall Research and Innovation goals.Job Description:The Research Fellow/Research Scientist will be responsible for engineering novel CAR-NK cells with superior anti-tumor efficacy, enhanced tumor infiltration, and excellent resilience against the...
-
Research Engineer
Found in: beBee S SG - 3 weeks ago
Singapore Imperial College London Full timeContract Type: Fixed-Term (24 months) /Contract Applications will be reviewed on a rolling basis, with final submission 15 April 2024. Imperial College London and Nanyang Technological University (NTU) are seeking Senior Research Fellows, Research Fellows, and Research Engineers to join the exciting new Imperial/NTU CYber Protection for HEalthcaRe...
-
Research Engineer
Found in: beBee S SG - 3 weeks ago
Singapore Imperial College London Full timeContract Type: Fixed-Term (24 months) /Contract Expires: 15th April 2024 Applications will be reviewed on a rolling basis, with final submission 15 April 2024. Imperial College London and Nanyang Technological University (NTU) are seeking Senior Research Fellows, Research Fellows, and Research Engineers to join the exciting new Imperial/NTU CYber Protection...
-
Research Engineer
Found in: beBee S SG - 3 weeks ago
Singapore Imperial College London Full timeContract Type: Fixed-Term (24 months) /Contract Expires: 15th April 2024 Applications will be reviewed on a rolling basis, with final submission 15 April 2024. Imperial College London and Nanyang Technological University (NTU) are seeking Senior Research Fellows, Research Fellows, and Research Engineers to join the exciting new Imperial/NTU CYber Protection...
-
Research Engineer
Found in: beBee S SG - 3 weeks ago
Singapore Imperial College London Full timeContract Type: Fixed-Term (24 months) /Contract Applications will be reviewed on a rolling basis, with final submission 15 April 2024. Imperial College London and Nanyang Technological University (NTU) are seeking Senior Research Fellows, Research Fellows, and Research Engineers to join the exciting new Imperial/NTU CYber Protection for HEalthcaRe...
-
Research Fellow
3 weeks ago
Singapore National University Of Singapore Full timeJob DescriptionThe National University of Singapore invites applications for the position of Research Fellow in the Department of Computer Science, School of Computing (SoC). SoC is strongly committed to research excellence in all its dimensions: Searching for fundamental results and insights in developing novel computational solutions to a wide range of...
-
Research Fellow
2 weeks ago
Singapore National University of Singapore Full timeJob DescriptionThe Research Fellow (RF) position is part of the research team working on advanced electroceramic materials and devices for new-generation techniques, where they require a set of robust dielectric properties, ultralow dielectric loss, and large tunability. The RF will be working on the electroceramics, thin films, their fabrication and...
-
Research Fellow
2 weeks ago
Singapore A*star Research Entities Full timeJOB DESCRIPTIONWe are seeking to recruit a highly motivated Research Fellow to investigate the rules in cancer antigen discovery, towards therapeutic and preventive therapy. Project involves mass spectrometry, immunology and computation. Initial contract of 2 years, extendable for another 2 years subject to positive performance.JOB REQUIREMENTPh.D. in...
-
Singapore National University of Singapore Full timeSenior Research Fellow/Research Fellow in International Relations (South Asia)The Institute of South Asian Studies (ISAS) at the National University of Singapore invites applications for a Senior Research Fellow or Research Fellow in International Relations to commence inAugust 2024or as soon as possible thereafter. The successful candidate will be part of...
-
Research Fellow
6 days ago
Singapore A*star Research Entities Full timeJob descriptionThe Research Fellow in Bioinformatics will play a key role in advancing our research initiatives by providing expert analysis of next-generation sequencing (NGS), focusing on single-cell sequencing, epigenetics data (including ChIP-seq and Ribo-seq), and integrating various multi-omics datasets. This position offers a unique opportunity to...
-
Research Fellow I
2 weeks ago
Singapore Singapore University of Technology & Design Full timeThe NSoE Phase II IoT Sector is looking to hire Research Fellows. Each Research Fellow will contribute in at least one of the following:Research on automated vulnerability discovery (e.g., via Fuzzing) in IoT (Wireless) networked systemsResearch on IoT honeypot and threat intelligence.Qualification & Experience:PhD degree in Computer Science, Computer...
-
Research Fellow
2 weeks ago
Singapore NTU (Nanyang Technology University- Main Office-HR) Full timeLee Kong Chian School of Medicine is recruiting a highly motivated Research Fellow (RF) / Senior Research Fellow (SRF) in Associate Professor Yasunori Saheki's lab. His lab is built on diversity, mutual respect, teamwork, and collaboration, with a special emphasis on providing mentorship for young talent, including students and postdocs. We will provide...
-
Research Fellow
2 weeks ago
Singapore National University of Singapore Full timeJob DescriptionA Research Fellow (Postdoctoral) position is available immediately in the laboratory of Assistant Prof. TANG Wei at the National University of Singapore (NUS) (). We are looking for highly motivated and competent research fellows to work on research focusing on building new generation drug delivery technologies for disease visualization,...
-
Research Fellow
2 weeks ago
Singapore National University Of Singapore Full timeJob Description The Duke-NUS Laboratory for Translational and Molecular Imaging (LTMI), Duke-NUS Medical School, is recruiting a Research Fellow/Senior Research Fellow to lead state-of-the-art small animal imaging studies in Viral Infectious Disease. LTMI aims to develop local infrastructure and deep capabilities in the development of molecular imaging...
