Research Associate
1 month ago
The appointed Research Associate will be based at the Lee Kong Chian School of Medicine, located in the Clinical Sciences Building Novena campus. LKCMedicine has a broad range of research programs and interdisciplinary research centers that host a range of leading research teams to conduct frontier biomedical research. Dr Xia's group is internationally recognized for its contribution in the research area of human stem cell derived kidney organoids. To establish kidney organoids that are suitable for disease modeling and drug validation, Dr Xia's group employed a multidisciplinary approach, including stem cell differentiation, multicellular self-organization, scRNAseq, high-content imaging, genetic perturbation, xenotransplantation, and etc. Key projects in Dr Xia's group includes testing drugs for treating PKD in organoid xenograft models, modeling ccRCC initiation using gene edited kidney organoids, and establishing organoid models for studying diabetic kidney disease, etc. Ultimately, Dr Xia's group aims to translate basic research outcome into therapeutic methodologies that can benefit patients. To accomplish this, Dr. Xia's team actively seeks industrial and clinical collaborations to promote translational science.
The appointed Research Associate is expected to play an important role in the project entitled "Preclinical evaluation of candidate PKD drugs in kidney organoid xenograft model and genetic animal model". The appointee will support a range of experiments for this research project, including stem cell culture, organoid differentiation, tissue histology and imaging, etc.
Key responsibilities:
- Responsible for lab mouse breeding, genotyping, and experimenting.
- Provide technical support to other lab researchers, such as Research Follows and PhD students.
- Manage centralized cell culture, frozen cell stocks, reagent preparation and quality control.
- Request quotation, negotiate price, prepare purchasing request, update purchasing record, prepare safety issue related paperwork (BPN and IACUC applications).
- Prepare the inventory lists for lab regents, cell lines, animal breeding record. Assign lab duties to lab personnel.
- Liaise with industrial collaborators and coordinate collaboration between academia and industry, and promote industrialization of some research outcome.
Key competencies and requirements:
- Candidates need to have a Master's degree in relevant field of molecular and cell biology, biochemistry, biotechnology, bioengineering, or other life sciences.
- Prior knowledge in microscopy imaging is preferred. Experimental skills in molecular biology (CRISPR-Cas9 gene editing tool) and biochemistry will be adding an advantage.
- Applicants who have substantial experience in industry will be given priority.
- Self-motivated and well-organized with good communication and technical skills.
- Be able to work independently and collaborate effectively in a highly diverse and interdisciplinary team.
Hiring Institution: LKC
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