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Research Associate
4 months ago
Cardiovascular diseases (CVDs) are a significant contributor to mortality. Atherosclerosis, characterized by the buildup of plaques containing fats, cholesterol, and other substances on arterial walls, is a major factor in CVDs. Detecting plaques early can aid in planning effective treatments to halt their progression. Magnetic resonance imaging (MRI) is commonly used for visualization but lacks an efficient contrast agent to distinguish plaque stages. This project proposes using engineered protein nanoparticles (PNPs) to enhance plaque contrast and staging. TThree specific phase will be designed: engineering PNPs for plaque targeting, evaluating contrast enhancement and tracking plaque progression in vivo. Results are expected to advance understanding of PNP-cell interactions within plaques, aiding future contrast agent development for atherosclerosis staging.
Key Responsibilities:
- Setting up protocols for animal study of the biodistribution of protein cage in mouse model;
- Executing experiments to achieve the specific aims of the project;
- Presenting results in various meetings/forums;
- Preparing reports for submission to the funding agency;
- Liaising with other scientists in the team as well as in other groups to develop the required expertise;
- Advising final year project and/or interns in the project.
Job Requirements:
- Master's in Biology, bioengineering, materials science or related fields
- Working knowledge in animal handling, especially atherosclerotic model
- Working knowledge in protein production using E. coli and purification using AKTA FPLC
- Familiarity in protein cage handling
- Highly preferred skills: familiarity with atherosclerosis
- Able to design and execute experiments with minimal instructions
- Good communication skills in both verbal and written forms
- Take initiatives and lead a project and ensure delivery of outcomes in a timely manner
- Team player who will take part in general lab activities
Candidates with experience in any of these fields, nanoparticles formulation and characterization, nanomedicine, in vivo experiment, are strongly encouraged to apply.
We regret that only shortlisted candidates will be notified.
Hiring Institution: NTU